Trpv protein family—from mechanosensing to cancer invasion

Tytti Kärki, Sari Tojkander*

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

1 Citation (Scopus)
4 Downloads (Pure)

Abstract

Biophysical cues from the cellular microenvironment are detected by mechanosensitive machineries that translate physical signals into biochemical signaling cascades. At the crossroads of extracellular space and cell interior are located several ion channel families, including TRP family proteins, that are triggered by mechanical stimuli and drive intracellular signaling pathways through spatio-temporally controlled Ca2+-influx. Mechanosensitive Ca2+-channels, therefore, act as critical components in the rapid transmission of physical signals into biologically compatible information to impact crucial processes during development, morphogenesis and regeneration. Given the mechanosensitive nature of many of the TRP family channels, they must also respond to the biophysical changes along the development of several pathophysiological conditions and have also been linked to cancer progression. In this review, we will focus on the TRPV, vanilloid family of TRP proteins, and their connection to cancer progression through their mechanosensitive nature.

Original languageEnglish
Article number1019
Number of pages23
JournalBIOMOLECULES
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 2021
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Cancer
  • Invasion
  • Mechanosensing
  • TRPV

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