Trends and burden of diabetes in patients with atrial fibrillation during 2007–2018 : A Finnish nationwide cohort study

Konsta Teppo*, Elis Kouki, Birgitta Salmela, Leo Niskanen, Jussi Jaakkola, Olli Halminen, Jari Haukka, Jukka Putaala, Miika Linna, Pirjo Mustonen, Juha Hartikainen, K. E. Juhani Airaksinen, Mika Lehto

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Aims: We assessed the temporal trends in the prevalence of diabetes and in its associations with outcomes among patients with atrial fibrillation (AF). Methods: The registry-based FinACAF study covered all patients with incident AF in Finland between 2007 and 2018. Ischemic stroke (IS) and mortality rates were computed using Poisson regression model. Results: We identified 229 565 patients (50.0% female; mean age 72.7 years; mean follow-up 4.0 years) patients with incident AF. The prevalence of diabetes increased steadily from 15.5% in 2007 to 26.3% in 2018. A decrease in IS and mortality rates was observed during the study period both in patients with and without diabetes. Diabetes was associated with IS and mortality (adjusted incidence rate ratios with 95% confidence intervals 1.22 (1.17–1.26) and 1.32 (1.29–1.34), respectively). The impact of diabetes on IS risk remained stable, while its effect on mortality increased slightly during the observation period. Conclusions: The prevalence of diabetes has increased considerably among patients with AF between 2007 and 2018. There have been substantial improvements in the prognosis of AF patients with diabetes. However, diabetes remains a significant risk factor for IS and mortality in this patient population.

Original languageEnglish
Article number110875
Pages (from-to)1-7
Number of pages7
JournalDiabetes Research and Clinical Practice
Publication statusPublished - Sept 2023
MoE publication typeA1 Journal article-refereed


  • Atrial fibrillation
  • Diabetes
  • Ischemic stroke
  • Mortality
  • Prevalence
  • Prognosis
  • Trends


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