Towards the Total Synthesis of Manzaminoïds

Research output: ThesisDoctoral ThesisMonograph


For the last decades, our laboratory has been interested in the development of new synthetic methodologies and their application to the total syntheses of natural products exhibiting biological activities. In this context, our investigation focused on the conception of new potential bioactive manzamine derivatives. For this purpose, new molecules were synthetized using novel approaches of anionic polycyclization. Three methodologies were developed allowing to reach our targets. On top of that, some mechanistical analyses were made to rationalize the observed diastereoselectivities. Finally, the derivatisation of some target molecules allowed us to quickly extend our library of bioactive compounds.
Translated title of the contributionTowards the Total Synthesis of Manzaminoïds
Original languageEnglish
QualificationDoctor's degree
Awarding Institution
  • Aalto University
  • Koskinen, Ari, Supervising Professor
  • Riant, Olivier, Supervising Professor
  • Solberghe, Geoffrey, Thesis Advisor
  • Dumeunier, Raphaël, Thesis Advisor
Print ISBNs978-952-60-8400-8
Electronic ISBNs978-952-60-8401-5
Publication statusPublished - 2019
MoE publication typeG4 Doctoral dissertation (monograph)


  • synthetic methodologies
  • natural products
  • bioactive manzamine derivatives
  • anionic polycyclization


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