Towards the Total Synthesis of Manzaminoïds

For the last decades, our laboratory has been interested in the development of new synthetic methodologies and their application to the total syntheses of natural products exhibiting biological activities. In this context, our investigation focused on the conception of new potential bioactive manzamine derivatives. For this purpose, new molecules were synthetized using novel approaches of anionic polycyclization. Three methodologies were developed allowing to reach our targets. On top of that, some mechanistical analyses were made to rationalize the observed diastereoselectivities. Finally, the derivatisation of some target molecules allowed us to quickly extend our library of bioactive compounds.