Towards Chronic Wound Pads: Gradient Nanofiber Structure Generated by Ultrasound Enhanced Electrospinning (USES)

Joel Hunnakko, Ivo Laidmäe, Tuomas Puranen, Joni Mäkinen, Petteri Helander, Heikki Nieminen, Anton Nolvi, Karin Kogermann, Jyrki Heinämäki, Ari Salmi, Edward Hæggström

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review


We utilized an ultrasound enhanced electrospinning (USES) technique to produce a four-layer nanofiber scaffold. In contrast to ordinary electrospinning (ES), in the USES process, acoustic radiation pressure generates a cone at the free surface of the polymer solution (4-wt% polyethylene oxide (PEO); aqueous solution), which replaces the need for the needle employed in traditional ES. The cone shape and size were modified by changing the ultrasound parameters (pulse repetition rate, cycles per pulse, and amplitude) during the electrospinning process. A four-layer sample was generated and imaged using scanning electron microscope. The produced nanofiber construct is the first demonstration of a needle-free electrospinning process featuring accurate control of fiber diameter without changes in the sample chemistry. These kinds of gradient structures could be utilized for generation of precision tailored wound pads.
Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium (IUS)
Number of pages3
ISBN (Electronic)978-1-7281-4596-9
Publication statusPublished - 9 Dec 2019
MoE publication typeA4 Article in a conference publication
EventIEEE International Ultrasonics Symposium - Glasgow, United Kingdom
Duration: 6 Oct 20199 Oct 2019

Publication series

NameIEEE International Ultrasonics Symposium
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


ConferenceIEEE International Ultrasonics Symposium
Abbreviated titleIUS
Country/TerritoryUnited Kingdom


  • gradient structures
  • nanofibers
  • ultrasound enhanced electrospinning
  • wound pad


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