Toward higher-performance bionic limbs for wider clinical use

Dario Farina; Ivan Vujaklija; Rickard Brånemark; Anthony M.J. Bull; Hans Dietl; Bernhard Graimann; Levi J. Hargrove; Klaus Peter Hoffmann; He (Helen) Huang; Thorvaldur Ingvarsson; Hilmar Bragi Janusson; Kristleifur Kristjánsson; Todd Kuiken; Silvestro Micera; Thomas Stieglitz; Agnes Sturma; Dustin Tyler; Richard F.ff Weir; Oskar C. Aszmann

doi:10.1038/s41551-021-00732-x

Toward higher-performance bionic limbs for wider clinical use

Dario Farina^*, Ivan Vujaklija, Rickard Brånemark, Anthony M.J. Bull, Hans Dietl, Bernhard Graimann, Levi J. Hargrove, Klaus Peter Hoffmann, He (Helen) Huang, Thorvaldur Ingvarsson, Hilmar Bragi Janusson, Kristleifur Kristjánsson, Todd Kuiken, Silvestro Micera, Thomas Stieglitz, Agnes Sturma, Dustin Tyler, Richard F.ff Weir, Oskar C. Aszmann

^*Corresponding author for this work

Research output: Contribution to journal › Review Article › peer-review

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Abstract

Most prosthetic limbs can autonomously move with dexterity, yet they are not perceived by the user as belonging to their own body. Robotic limbs can convey information about the environment with higher precision than biological limbs, but their actual performance is substantially limited by current technologies for the interfacing of the robotic devices with the body and for transferring motor and sensory information bidirectionally between the prosthesis and the user. In this Perspective, we argue that direct skeletal attachment of bionic devices via osseointegration, the amplification of neural signals by targeted muscle innervation, improved prosthesis control via implanted muscle sensors and advanced algorithms, and the provision of sensory feedback by means of electrodes implanted in peripheral nerves, should all be leveraged towards the creation of a new generation of high-performance bionic limbs. These technologies have been clinically tested in humans, and alongside mechanical redesigns and adequate rehabilitation training should facilitate the wider clinical use of bionic limbs.

Original language	English
Pages (from-to)	473-485
Number of pages	13
Journal	Nature Biomedical Engineering
Volume	7
Issue number	4
Early online date	31 May 2021
DOIs	https://doi.org/10.1038/s41551-021-00732-x
Publication status	Published - Apr 2023
MoE publication type	A2 Review article, Literature review, Systematic review

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ELEC_Farina_etal_Toward_higher-performance_bionic_limbs_NatBioMedEng_2021_acceptedauthormanuscriptAccepted author manuscript, 856 KB

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Farina, D., Vujaklija, I., Brånemark, R., Bull, A. M. J., Dietl, H., Graimann, B., Hargrove, L. J., Hoffmann, K. P., Huang, H., Ingvarsson, T., Janusson, H. B., Kristjánsson, K., Kuiken, T., Micera, S., Stieglitz, T., Sturma, A., Tyler, D., Weir, R. F. F., & Aszmann, O. C. (2023). Toward higher-performance bionic limbs for wider clinical use. Nature Biomedical Engineering, 7(4), 473-485. https://doi.org/10.1038/s41551-021-00732-x

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title = "Toward higher-performance bionic limbs for wider clinical use",

abstract = "Most prosthetic limbs can autonomously move with dexterity, yet they are not perceived by the user as belonging to their own body. Robotic limbs can convey information about the environment with higher precision than biological limbs, but their actual performance is substantially limited by current technologies for the interfacing of the robotic devices with the body and for transferring motor and sensory information bidirectionally between the prosthesis and the user. In this Perspective, we argue that direct skeletal attachment of bionic devices via osseointegration, the amplification of neural signals by targeted muscle innervation, improved prosthesis control via implanted muscle sensors and advanced algorithms, and the provision of sensory feedback by means of electrodes implanted in peripheral nerves, should all be leveraged towards the creation of a new generation of high-performance bionic limbs. These technologies have been clinically tested in humans, and alongside mechanical redesigns and adequate rehabilitation training should facilitate the wider clinical use of bionic limbs.",

author = "Dario Farina and Ivan Vujaklija and Rickard Br{\aa}nemark and Bull, {Anthony M.J.} and Hans Dietl and Bernhard Graimann and Hargrove, {Levi J.} and Hoffmann, {Klaus Peter} and Huang, {He (Helen)} and Thorvaldur Ingvarsson and Janusson, {Hilmar Bragi} and Kristleifur Kristj{\'a}nsson and Todd Kuiken and Silvestro Micera and Thomas Stieglitz and Agnes Sturma and Dustin Tyler and Weir, {Richard F.ff} and Aszmann, {Oskar C.}",

note = "Funding Information: We were supported by the Academy of Finland (I.V.), Austrian Federal Ministry of Science (A.S. and O.C.A.), Bertarelli Foundation (S.M.), the European Union (A.S., D.F., K.-P.H., O.C.A., R.B. and S.M.), the European Research Council (A.S., D.F. and O.C.A.), German Federal Ministry of Education and Research BMBF (K.-P.H. and T.S.), the German National Research Foundation (T.S.), the Royal British Legion (A.M.J.B.), the Swedish Innovation Agency (VINNOVA) (R.B.), the Swedish Research Council (R.B.), the Swiss National Competence Center in Research (NCCR) in Robotics (S.M.), US Department of Defense (R.B. and H.H.), US Department of Veterans Affairs (D.T.), US Department of Veterans Affairs Rehabilitation Research and Development Service (R.F.ff.W.), US National Institute on Disability, Independent Living and Rehabilitation Research (H.H. and T.K.), US National Institutes of Health (D.T., H.H., L.J.H. and R.F.ff.W.), US National Institute on Neurological Disorders and Stroke (R.F.ff.W.), US National Institute on Bioimaging and Bioengineering (R.F.ff.W.) and US National Science Foundation (H.H.). Publisher Copyright: {\textcopyright} 2021, Springer Nature Limited.",

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doi = "10.1038/s41551-021-00732-x",

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Farina, D, Vujaklija, I, Brånemark, R, Bull, AMJ, Dietl, H, Graimann, B, Hargrove, LJ, Hoffmann, KP, Huang, H, Ingvarsson, T, Janusson, HB, Kristjánsson, K, Kuiken, T, Micera, S, Stieglitz, T, Sturma, A, Tyler, D, Weir, RFF & Aszmann, OC 2023, 'Toward higher-performance bionic limbs for wider clinical use', Nature Biomedical Engineering, vol. 7, no. 4, pp. 473-485. https://doi.org/10.1038/s41551-021-00732-x

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T1 - Toward higher-performance bionic limbs for wider clinical use

AU - Farina, Dario

AU - Vujaklija, Ivan

AU - Brånemark, Rickard

AU - Bull, Anthony M.J.

AU - Dietl, Hans

AU - Graimann, Bernhard

AU - Hargrove, Levi J.

AU - Hoffmann, Klaus Peter

AU - Huang, He (Helen)

AU - Ingvarsson, Thorvaldur

AU - Janusson, Hilmar Bragi

AU - Kristjánsson, Kristleifur

AU - Kuiken, Todd

AU - Micera, Silvestro

AU - Stieglitz, Thomas

AU - Sturma, Agnes

AU - Tyler, Dustin

AU - Weir, Richard F.ff

AU - Aszmann, Oskar C.

N1 - Funding Information: We were supported by the Academy of Finland (I.V.), Austrian Federal Ministry of Science (A.S. and O.C.A.), Bertarelli Foundation (S.M.), the European Union (A.S., D.F., K.-P.H., O.C.A., R.B. and S.M.), the European Research Council (A.S., D.F. and O.C.A.), German Federal Ministry of Education and Research BMBF (K.-P.H. and T.S.), the German National Research Foundation (T.S.), the Royal British Legion (A.M.J.B.), the Swedish Innovation Agency (VINNOVA) (R.B.), the Swedish Research Council (R.B.), the Swiss National Competence Center in Research (NCCR) in Robotics (S.M.), US Department of Defense (R.B. and H.H.), US Department of Veterans Affairs (D.T.), US Department of Veterans Affairs Rehabilitation Research and Development Service (R.F.ff.W.), US National Institute on Disability, Independent Living and Rehabilitation Research (H.H. and T.K.), US National Institutes of Health (D.T., H.H., L.J.H. and R.F.ff.W.), US National Institute on Neurological Disorders and Stroke (R.F.ff.W.), US National Institute on Bioimaging and Bioengineering (R.F.ff.W.) and US National Science Foundation (H.H.). Publisher Copyright: © 2021, Springer Nature Limited.

PY - 2023/4

Y1 - 2023/4

N2 - Most prosthetic limbs can autonomously move with dexterity, yet they are not perceived by the user as belonging to their own body. Robotic limbs can convey information about the environment with higher precision than biological limbs, but their actual performance is substantially limited by current technologies for the interfacing of the robotic devices with the body and for transferring motor and sensory information bidirectionally between the prosthesis and the user. In this Perspective, we argue that direct skeletal attachment of bionic devices via osseointegration, the amplification of neural signals by targeted muscle innervation, improved prosthesis control via implanted muscle sensors and advanced algorithms, and the provision of sensory feedback by means of electrodes implanted in peripheral nerves, should all be leveraged towards the creation of a new generation of high-performance bionic limbs. These technologies have been clinically tested in humans, and alongside mechanical redesigns and adequate rehabilitation training should facilitate the wider clinical use of bionic limbs.

AB - Most prosthetic limbs can autonomously move with dexterity, yet they are not perceived by the user as belonging to their own body. Robotic limbs can convey information about the environment with higher precision than biological limbs, but their actual performance is substantially limited by current technologies for the interfacing of the robotic devices with the body and for transferring motor and sensory information bidirectionally between the prosthesis and the user. In this Perspective, we argue that direct skeletal attachment of bionic devices via osseointegration, the amplification of neural signals by targeted muscle innervation, improved prosthesis control via implanted muscle sensors and advanced algorithms, and the provision of sensory feedback by means of electrodes implanted in peripheral nerves, should all be leveraged towards the creation of a new generation of high-performance bionic limbs. These technologies have been clinically tested in humans, and alongside mechanical redesigns and adequate rehabilitation training should facilitate the wider clinical use of bionic limbs.

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U2 - 10.1038/s41551-021-00732-x

DO - 10.1038/s41551-021-00732-x

M3 - Review Article

C2 - 34059810

AN - SCOPUS:85107532112

SN - 2157-846X

VL - 7

SP - 473

EP - 485

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

IS - 4

ER -

Toward higher-performance bionic limbs for wider clinical use

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Hi-Fi BiNDIng: High-Fidelity Bidirectional Neural Drive Interfacing (Hi-Fi BiNDIng) - Framework for investigating and restoration of human upper limb sensory/motor function

Findings on Robotics Detailed by Investigators at Imperial College London (Toward Higher-performance Bionic Limbs for Wider Clinical Use)

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Toward higher-performance bionic limbs for wider clinical use

Abstract

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Hi-Fi BiNDIng: High-Fidelity Bidirectional Neural Drive Interfacing (Hi-Fi BiNDIng) - Framework for investigating and restoration of human upper limb sensory/motor function

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Findings on Robotics Detailed by Investigators at Imperial College London (Toward Higher-performance Bionic Limbs for Wider Clinical Use)

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