Topological analysis of interaction patterns in cancer-specific gene regulatory network: persistent homology approach

Hosein Masoomy, Behrouz Askari, Samin Tajik, Abbas K. Rizi, G. Reza Jafari*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
17 Downloads (Pure)

Abstract

In this study, we investigated cancer cellular networks in the context of gene interactions and their associated patterns in order to recognize the structural features underlying this disease. We aim to propose that the quest of understanding cancer takes us beyond pairwise interactions between genes to a higher-order construction. We characterize the most prominent network deviations in the gene interaction patterns between cancer and normal samples that contribute to the complexity of this disease. What we hope is that through understanding these interaction patterns we will notice a deeper structure in the cancer network. This study uncovers the significant deviations that topological features in cancerous cells show from the healthy one, where the last stage of filtration confirms the importance of one-dimensional holes (topological loops) in cancerous cells and two-dimensional holes (topological voids) in healthy cells. In the small threshold region, the drop in the number of connected components of the cancer network, along with the rise in the number of loops and voids, all occurring at some smaller weight values compared to the normal case, reveals the cancerous network tendency to certain pathways.

Original languageEnglish
Article number16414
Number of pages11
JournalScientific Reports
Volume11
Issue number1
DOIs
Publication statusPublished - 12 Aug 2021
MoE publication typeA1 Journal article-refereed

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