THz Imaging System for in vivo Human Cornea

Shijun Sung*, Skyler Selvin, Neha Bajwa, Somporn Chantra, Bryan Nowroozi, James Garritano, Jacob Goell, Alexander D. Li, Sophie X. Deng, Elliott R. Brown, Warren S. Grundfest, Zachary D. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)

Abstract

Terahertz (THz) imaging of corneal tissue water content (CTWC) is a proposed method for early, accurate detection and study of corneal diseases. Despite promising results from ex vivo and in vivo cornea studies, interpretation of the reflectivity data is confounded by the contact between corneal tissue and rigid dielectric window used to flatten the imaging field. This work develops a novel imaging system and image reconstruction methods specifically for nearly spherical targets such as human cornea. A prototype system was constructed using a 650-GHz multiplier source and Schottky diode detector. Resolution and imaging field strength measurement from characterization targets correlate well with those predicted by the quasioptical theory and physical optics analysis. Imaging experiments with corneal phantoms and ex vivo corneas demonstrate the hydration sensitivity of the imaging system and reliable measurement of CTWC. We present successful acquisition of noncontact THz images of in vivo human cornea, and discuss strategies for optimizing the imaging system design for clinical use.

Original languageEnglish
Article number8167336
Pages (from-to)27-37
Number of pages11
JournalIEEE Transactions on Terahertz Science and Technology
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018
MoE publication typeA1 Journal article-refereed

Keywords

  • Biological and medical imaging
  • clinical instruments
  • medical diagnostics
  • terahertz (THz) imaging of cornea

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    Sung, S., Selvin, S., Bajwa, N., Chantra, S., Nowroozi, B., Garritano, J., ... Taylor, Z. D. (2018). THz Imaging System for in vivo Human Cornea. IEEE Transactions on Terahertz Science and Technology, 8(1), 27-37. [8167336]. https://doi.org/10.1109/TTHZ.2017.2775445