Thiol-ene-based, replicated, high-aspect ratio micropillar arrays as immobilized chymotrypsin reactors

Sari Tähkä*, Riccardo Provenzani, Gustav Boije Af Gennäs, Jari Yli-Kauhaluoma, Ville Jokinen, Tiina Sikanen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Abstract

We present a new non-cleanroom-based replication approach for implementation of high aspect ratio (h=200 μm, d=50 μm) micropillar arrays out of thiol-enes followed by biofunctionalization with chymotrypsin. Our approach exploits gold nanoparticles (GNPs) to bind the enzymes on the thiol-ene surfaces via gold-thiol chemistry.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Pages1491-1492
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
MoE publication typeA4 Article in a conference publication
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences - Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016
Conference number: 20

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleMicroTAS 2016
CountryIreland
CityDublin
Period09/10/201613/10/2016

Keywords

  • Gold nanoparticles
  • Immobilized enzyme microreactors
  • Replica molding
  • Thiol-enes

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