Theta-Band Oscillations as an Indicator of Mild Traumatic Brain Injury

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Theta-Band Oscillations as an Indicator of Mild Traumatic Brain Injury. / Kaltiainen, Hanna; Helle, Liisa; Liljeström, Mia; Renvall, Hanna; Forss, Nina.

In: Brain Topography, Vol. 31, No. 6, 2018, p. 1037-1046.

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@article{6e69b40a159343058a2b036a3c59def5,
title = "Theta-Band Oscillations as an Indicator of Mild Traumatic Brain Injury",
abstract = "Mild traumatic brain injury (mTBI) patients continue to pose a diagnostic challenge due to their diverse symptoms without trauma-specific changes in structural imaging. We addressed here the possible early changes in spontaneous oscillatory brain activity after mTBI, and their feasibility as an indicator of injury in clinical evaluation. We recorded resting-state magnetoencephalography (MEG) data in both eyes-open and eyes-closed conditions from 26 patients (11 females and 15 males, aged 20–59) with mTBI 6 days–6 months after the injury, and compared their spontaneous oscillatory activity to corresponding data from 139 healthy controls. Twelve of the patients underwent a follow-up measurement at 6 months. Ten of all patients were without structural lesions in MRI. At single-subject level, aberrant 4–7 Hz (theta) band activity exceeding the + 2 SD limit of the healthy subjects was visible in 7 out of 26 patients; three out of the seven patients with abnormal theta activity were without any detectable lesions in MRI. Of the patients that participated in the follow-up measurements, five showed abnormal theta activity in the first recording, but only two in the second measurement. Our results suggest that aberrant theta-band oscillatory activity can provide an early objective sign of brain dysfunction after mTBI. In 3/7 patients, the slow-wave activity was transient and visible only in the first recording, urging prompt timing for the measurements in clinical settings.",
keywords = "Low frequency activity, Magnetoencephalography (MEG), Oscillations, Repeated measurements, Resting-state, Traumatic brain injury (TBI)",
author = "Hanna Kaltiainen and Liisa Helle and Mia Liljestr{\"o}m and Hanna Renvall and Nina Forss",
year = "2018",
doi = "10.1007/s10548-018-0667-2",
language = "English",
volume = "31",
pages = "1037--1046",
journal = "Brain Topography, Springer, New York",
issn = "0896-0267",
number = "6",

}

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TY - JOUR

T1 - Theta-Band Oscillations as an Indicator of Mild Traumatic Brain Injury

AU - Kaltiainen, Hanna

AU - Helle, Liisa

AU - Liljeström, Mia

AU - Renvall, Hanna

AU - Forss, Nina

PY - 2018

Y1 - 2018

N2 - Mild traumatic brain injury (mTBI) patients continue to pose a diagnostic challenge due to their diverse symptoms without trauma-specific changes in structural imaging. We addressed here the possible early changes in spontaneous oscillatory brain activity after mTBI, and their feasibility as an indicator of injury in clinical evaluation. We recorded resting-state magnetoencephalography (MEG) data in both eyes-open and eyes-closed conditions from 26 patients (11 females and 15 males, aged 20–59) with mTBI 6 days–6 months after the injury, and compared their spontaneous oscillatory activity to corresponding data from 139 healthy controls. Twelve of the patients underwent a follow-up measurement at 6 months. Ten of all patients were without structural lesions in MRI. At single-subject level, aberrant 4–7 Hz (theta) band activity exceeding the + 2 SD limit of the healthy subjects was visible in 7 out of 26 patients; three out of the seven patients with abnormal theta activity were without any detectable lesions in MRI. Of the patients that participated in the follow-up measurements, five showed abnormal theta activity in the first recording, but only two in the second measurement. Our results suggest that aberrant theta-band oscillatory activity can provide an early objective sign of brain dysfunction after mTBI. In 3/7 patients, the slow-wave activity was transient and visible only in the first recording, urging prompt timing for the measurements in clinical settings.

AB - Mild traumatic brain injury (mTBI) patients continue to pose a diagnostic challenge due to their diverse symptoms without trauma-specific changes in structural imaging. We addressed here the possible early changes in spontaneous oscillatory brain activity after mTBI, and their feasibility as an indicator of injury in clinical evaluation. We recorded resting-state magnetoencephalography (MEG) data in both eyes-open and eyes-closed conditions from 26 patients (11 females and 15 males, aged 20–59) with mTBI 6 days–6 months after the injury, and compared their spontaneous oscillatory activity to corresponding data from 139 healthy controls. Twelve of the patients underwent a follow-up measurement at 6 months. Ten of all patients were without structural lesions in MRI. At single-subject level, aberrant 4–7 Hz (theta) band activity exceeding the + 2 SD limit of the healthy subjects was visible in 7 out of 26 patients; three out of the seven patients with abnormal theta activity were without any detectable lesions in MRI. Of the patients that participated in the follow-up measurements, five showed abnormal theta activity in the first recording, but only two in the second measurement. Our results suggest that aberrant theta-band oscillatory activity can provide an early objective sign of brain dysfunction after mTBI. In 3/7 patients, the slow-wave activity was transient and visible only in the first recording, urging prompt timing for the measurements in clinical settings.

KW - Low frequency activity

KW - Magnetoencephalography (MEG)

KW - Oscillations

KW - Repeated measurements

KW - Resting-state

KW - Traumatic brain injury (TBI)

UR - http://www.scopus.com/inward/record.url?scp=85051292149&partnerID=8YFLogxK

U2 - 10.1007/s10548-018-0667-2

DO - 10.1007/s10548-018-0667-2

M3 - Article

VL - 31

SP - 1037

EP - 1046

JO - Brain Topography, Springer, New York

JF - Brain Topography, Springer, New York

SN - 0896-0267

IS - 6

ER -

ID: 27419838