Theory of pore-driven and end-pulled polymer translocation dynamics through a nanopore: An overview

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Abstract

We review recent progress on the theory of dynamics of polymer translocation through a nanopore based on the iso-flux tension propagation (IFTP) theory. We investigate both pore-driven translocation of flexible and a semi-flexible polymers, and the end-pulled case of flexible chains by means of the IFTP theory and extensive molecular dynamics (MD) simulations. The validity of the IFTP theory can be quantified by the waiting time distributions of the monomers which reveal the details of the dynamics of the translocation process. The IFTP theory allows a parameter-free description of the translocation process and can be used to derive exact analytic scaling forms in the appropriate limits, including the influence due to the pore friction that appears as a finite-size correction to asymptotic scaling. We show that in the case of pore-driven semi-flexible and end-pulled polymer chains the IFTP theory must be augmented with an explicit trans side friction term for a quantitative description of the translocation process.

Original languageEnglish
Article number274002
Pages (from-to)1-13
JournalJournal of Physics Condensed Matter
Volume30
Issue number27
DOIs
Publication statusPublished - 12 Jun 2018
MoE publication typeA2 Review article in a scientific journal

Keywords

  • DNA sequencing
  • dynamics of polymer
  • nanopore
  • translocation

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