The nuclear medicine production and delivery problem

Research output: Contribution to journalArticleScientificpeer-review


  • Jongsung Lee
  • Byung In Kim
  • Andrew L. Johnson
  • Kiho Lee

Research units

  • Pohang University of Science and Technology
  • Texas A and M University


Half-life is a unique characteristic of radioactive substances used in a variety of medical treatments. Radioisotope F-18 used for diagnosing and monitoring many types of cancers has a half-life of 110 minutes. As such, it requires careful coordination of production and delivery by manufacturers and medical end-users. To model this critical production and delivery problem, we develop a mixed integer program and propose a variant of a large neighborhood search algorithm with various improvement algorithms. We conduct several computational experiments to demonstrate the effectiveness of the proposed approach. The method when applied in a case study shows that improvement in terms of both time and cost is possible in the production and delivery of F-18.


Original languageEnglish
Pages (from-to)461-472
Number of pages12
JournalEuropean Journal of Operational Research
Issue number2
Publication statusPublished - 16 Jul 2014
MoE publication typeA1 Journal article-refereed

    Research areas

  • Half-life, Large neighborhood search, Nuclear medicine, Production and delivery, Routing, Vehicle routing

ID: 9310664