The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems

Research output: Contribution to journalArticleScientificpeer-review

Researchers

  • Mirkka P. Sarparanta
  • Luis M. Bimbo
  • Ermei M. Makila
  • Jarno J. Salonen
  • Päivi Laaksonen
  • A. M. Kerttuli Helariutta
  • Markus B. Linder
  • Jouni T. Hirvonen
  • Timo J. Laaksonen
  • Helder A. Santos
  • Anu J. Airaksinen

Research units

  • VTT Technical Research Centre of Finland
  • University of Helsinki
  • University of Turku

Abstract

Impediments to intestinal absorption, such as poor solubility and instability in the variable conditions of the gastrointestinal (GI) tract plague many of the current drugs restricting their oral bioavailability. Particulate drug delivery systems hold great promise in solving these problems, but their effectiveness might be limited by their often rapid transit through the GI tract. Here we describe a bioadhesive oral drug delivery system based on thermally-hydrocarbonized porous silicon (THCPSi) functionalized with a self-assembled amphiphilic protein coating consisting of a class II hydrophobin (HFBII) from Trichoderma reesei. The HFBII-THCPSi nanoparticles were found to be non-cytotoxic and mucoadhesive in AGS cells, prompting their use in a biodistribution study in rats after oral administration. The passage of HFBII-THCPSi nanoparticles in the rat GI tract was significantly slower than that of uncoated THCPSi, and the nanoparticles were retained in stomach by gastric mucoadhesion up to 3 h after administration. Upon entry to the small intestine, the mucoadhesive properties were lost, resulting in the rapid transit of the nanoparticles through the remainder of the GI tract. The gastroretentive drug delivery system with a dual function presented here is a viable alternative for improving drug bioavailability in the oral route. (c) 2012 Elsevier Ltd. All rights reserved.

Details

Original languageEnglish
Pages (from-to)3353-3362
Number of pages10
JournalBiomaterials
Volume33
Issue number11
Publication statusPublished - Apr 2012
MoE publication typeA1 Journal article-refereed

    Research areas

  • Silicon, Hydrophobin, Nanoparticle, Drug delivery, Adhesion, Biocompatibility, MESOPOROUS SILICON, GASTROINTESTINAL-TRACT, PHARMACEUTICAL APPLICATIONS, TRICHODERMA-REESEI, DOSAGE FORMS, IN-VIVO, PARTICLES, SURFACE, MICROPARTICLES, PROTEINS

ID: 4463776