The Effect of Dual-Hemisphere Transcranial Direct Current Stimulation Over the Parietal Operculum on Tactile Orientation Discrimination

Shuhei Fujimoto; Satoshi Tanaka; Ilkka Laakso; Tomofumi Yamaguchi; Noriko Kon; Takeo Nakayama; Kunitsugu Kondo; Ryo Kitada

doi:10.3389/fnbeh.2017.00173

The Effect of Dual-Hemisphere Transcranial Direct Current Stimulation Over the Parietal Operculum on Tactile Orientation Discrimination

Shuhei Fujimoto
, Satoshi Tanaka
, Ilkka Laakso
, Tomofumi Yamaguchi
, Noriko Kon
, Takeo Nakayama
, Kunitsugu Kondo
, Ryo Kitada^*

^*Corresponding author for this work

Hamamatsu University School of Medicine
Kyoto University
Tokyo Bay Rehabilitation Hospital
Link & Communication Inc
Keio University
University of Copenhagen
Yamagata Prefectural University
Kawakita Rehabilitation Hospital
Nanyang Technological University

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

The parietal operculum (PO) often shows ipsilateral activation during tactile object perception in neuroimaging experiments. However, the relative contribution of the PO to tactile judgment remains unclear. Here, we examined the effect of transcranial direct current stimulation (tDCS) over bilateral PO to test the relative contributions of the ipsilateral PO to tactile object processing. Ten healthy adults participated in this study, which had a double-blind, sham-controlled, cross-over design. Participants discriminated grating orientation during three tDCS and sham conditions. In the dual-hemisphere tDCS conditions, anodal and cathodal electrodes were placed over the left and right PO. In the uni-hemisphere tDCS condition, anodal and cathodal electrodes were applied over the left PO and contralateral orbit, respectively. In the tDCS and sham conditions, we applied 2 mA for 15 min and for 15 s, respectively. Computational models of electric fields (EFs) during tDCS indicated that the strongest electric fields were located in regions in and around the PO. Compared with the sham condition, dual-hemisphere tDCS improved the discrimination threshold of the index finger contralateral to the anodal electrode. Importantly, dual-hemisphere tDCS with the anodal electrode over the left PO yielded a decreased threshold in the right finger compared with the uni-hemisphere tDCS condition. These results suggest that the ipsilateral PO inhibits tactile processing of grating orientation, indicating interhemispheric inhibition (IHI) of the PO.

Original language	English
Article number	173
Number of pages	11
Journal	Frontiers in Behavioral Neuroscience
Volume	11
DOIs	https://doi.org/10.3389/fnbeh.2017.00173
Publication status	Published - 20 Sept 2017
MoE publication type	A1 Journal article-refereed

Funding

This work was supported by grants from the Grants-in-Aid for Scientific Research (KAKENHI) to ST (16H03201 and 17H00869) and to RK (16H01680) from the Japan Society for the Promotion of Science (JSPS) and from Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. This work was also supported by a startup grant from Nanyang Technological Universtity to RK. We thank Benjamin Knight, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

Keywords

cortical plasticity
inter-hemispheric inhibition (IHI)
somatosensory cortex
tactile
transcranial direct current stimulation (tDCS)
transcranial magnetic stimulation (TMS)
HUMAN MOTOR CORTEX
PRIMARY SOMATOSENSORY CORTEX
RECEPTIVE-FIELD PROPERTIES
INTERHEMISPHERIC INHIBITION
GRATING ORIENTATION
CORTICAL SURFACE
MACAQUE MONKEYS
ELECTRIC-FIELDS
FINGER MOVEMENT
FUNCTIONAL MRI

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10.3389/fnbeh.2017.00173Licence: CC BY

Fujimoto_etal_fbn_11_173
Copyright © 2017 Fujimoto, Tanaka, Laakso, Yamaguchi, Kon, Nakayama, Kondo and Kitada. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Final published version, 1.88 MBLicence: CC BY

Cite this

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title = "The Effect of Dual-Hemisphere Transcranial Direct Current Stimulation Over the Parietal Operculum on Tactile Orientation Discrimination",

abstract = "The parietal operculum (PO) often shows ipsilateral activation during tactile object perception in neuroimaging experiments. However, the relative contribution of the PO to tactile judgment remains unclear. Here, we examined the effect of transcranial direct current stimulation (tDCS) over bilateral PO to test the relative contributions of the ipsilateral PO to tactile object processing. Ten healthy adults participated in this study, which had a double-blind, sham-controlled, cross-over design. Participants discriminated grating orientation during three tDCS and sham conditions. In the dual-hemisphere tDCS conditions, anodal and cathodal electrodes were placed over the left and right PO. In the uni-hemisphere tDCS condition, anodal and cathodal electrodes were applied over the left PO and contralateral orbit, respectively. In the tDCS and sham conditions, we applied 2 mA for 15 min and for 15 s, respectively. Computational models of electric fields (EFs) during tDCS indicated that the strongest electric fields were located in regions in and around the PO. Compared with the sham condition, dual-hemisphere tDCS improved the discrimination threshold of the index finger contralateral to the anodal electrode. Importantly, dual-hemisphere tDCS with the anodal electrode over the left PO yielded a decreased threshold in the right finger compared with the uni-hemisphere tDCS condition. These results suggest that the ipsilateral PO inhibits tactile processing of grating orientation, indicating interhemispheric inhibition (IHI) of the PO.",

keywords = "cortical plasticity, inter-hemispheric inhibition (IHI), somatosensory cortex, tactile, transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), HUMAN MOTOR CORTEX, PRIMARY SOMATOSENSORY CORTEX, RECEPTIVE-FIELD PROPERTIES, INTERHEMISPHERIC INHIBITION, GRATING ORIENTATION, CORTICAL SURFACE, MACAQUE MONKEYS, ELECTRIC-FIELDS, FINGER MOVEMENT, FUNCTIONAL MRI",

author = "Shuhei Fujimoto and Satoshi Tanaka and Ilkka Laakso and Tomofumi Yamaguchi and Noriko Kon and Takeo Nakayama and Kunitsugu Kondo and Ryo Kitada",

year = "2017",

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language = "English",

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T1 - The Effect of Dual-Hemisphere Transcranial Direct Current Stimulation Over the Parietal Operculum on Tactile Orientation Discrimination

AU - Fujimoto, Shuhei

AU - Tanaka, Satoshi

AU - Laakso, Ilkka

AU - Yamaguchi, Tomofumi

AU - Kon, Noriko

AU - Nakayama, Takeo

AU - Kondo, Kunitsugu

AU - Kitada, Ryo

PY - 2017/9/20

Y1 - 2017/9/20

N2 - The parietal operculum (PO) often shows ipsilateral activation during tactile object perception in neuroimaging experiments. However, the relative contribution of the PO to tactile judgment remains unclear. Here, we examined the effect of transcranial direct current stimulation (tDCS) over bilateral PO to test the relative contributions of the ipsilateral PO to tactile object processing. Ten healthy adults participated in this study, which had a double-blind, sham-controlled, cross-over design. Participants discriminated grating orientation during three tDCS and sham conditions. In the dual-hemisphere tDCS conditions, anodal and cathodal electrodes were placed over the left and right PO. In the uni-hemisphere tDCS condition, anodal and cathodal electrodes were applied over the left PO and contralateral orbit, respectively. In the tDCS and sham conditions, we applied 2 mA for 15 min and for 15 s, respectively. Computational models of electric fields (EFs) during tDCS indicated that the strongest electric fields were located in regions in and around the PO. Compared with the sham condition, dual-hemisphere tDCS improved the discrimination threshold of the index finger contralateral to the anodal electrode. Importantly, dual-hemisphere tDCS with the anodal electrode over the left PO yielded a decreased threshold in the right finger compared with the uni-hemisphere tDCS condition. These results suggest that the ipsilateral PO inhibits tactile processing of grating orientation, indicating interhemispheric inhibition (IHI) of the PO.

AB - The parietal operculum (PO) often shows ipsilateral activation during tactile object perception in neuroimaging experiments. However, the relative contribution of the PO to tactile judgment remains unclear. Here, we examined the effect of transcranial direct current stimulation (tDCS) over bilateral PO to test the relative contributions of the ipsilateral PO to tactile object processing. Ten healthy adults participated in this study, which had a double-blind, sham-controlled, cross-over design. Participants discriminated grating orientation during three tDCS and sham conditions. In the dual-hemisphere tDCS conditions, anodal and cathodal electrodes were placed over the left and right PO. In the uni-hemisphere tDCS condition, anodal and cathodal electrodes were applied over the left PO and contralateral orbit, respectively. In the tDCS and sham conditions, we applied 2 mA for 15 min and for 15 s, respectively. Computational models of electric fields (EFs) during tDCS indicated that the strongest electric fields were located in regions in and around the PO. Compared with the sham condition, dual-hemisphere tDCS improved the discrimination threshold of the index finger contralateral to the anodal electrode. Importantly, dual-hemisphere tDCS with the anodal electrode over the left PO yielded a decreased threshold in the right finger compared with the uni-hemisphere tDCS condition. These results suggest that the ipsilateral PO inhibits tactile processing of grating orientation, indicating interhemispheric inhibition (IHI) of the PO.

KW - cortical plasticity

KW - inter-hemispheric inhibition (IHI)

KW - somatosensory cortex

KW - tactile

KW - transcranial direct current stimulation (tDCS)

KW - transcranial magnetic stimulation (TMS)

KW - HUMAN MOTOR CORTEX

KW - PRIMARY SOMATOSENSORY CORTEX

KW - RECEPTIVE-FIELD PROPERTIES

KW - INTERHEMISPHERIC INHIBITION

KW - GRATING ORIENTATION

KW - CORTICAL SURFACE

KW - MACAQUE MONKEYS

KW - ELECTRIC-FIELDS

KW - FINGER MOVEMENT

KW - FUNCTIONAL MRI

U2 - 10.3389/fnbeh.2017.00173

DO - 10.3389/fnbeh.2017.00173

M3 - Article

SN - 1662-5153

VL - 11

JO - Frontiers in Behavioral Neuroscience

JF - Frontiers in Behavioral Neuroscience

M1 - 173

ER -

The Effect of Dual-Hemisphere Transcranial Direct Current Stimulation Over the Parietal Operculum on Tactile Orientation Discrimination

Abstract

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Keywords

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