The cerebellum generates motor-to-auditory predictions: ERP lesion evidence

Franziska Knolle*, Erich Schröger, Pamela Baess, Sonja A. Kotz

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

65 Citations (Scopus)

Abstract

Forward predictions are crucial in motor action (e.g., catching a ball, or being tickled) but may also apply to sensory or cognitive processes (e.g., listening to distorted speech or to a foreign accent). According to the "internal forward model," the cerebellum generates predictions about somatosensory consequences of movements. These predictions simulate motor processes and prepare respective cortical areas for anticipated sensory input. Currently, there is very little evidence that a cerebellar forward model also applies to other sensory domains. In the current study, we address this question by examining the role of the cerebellum when auditory stimuli are anticipated as a consequence of a motor act. We applied an N100 suppression paradigm and compared the ERP in response to self-initiated with the ERP response to externally produced sounds. We hypothesized that sensory consequences of self-initiated sounds are precisely predicted and should lead to an N100 suppression compared with externally produced sounds. Moreover, if the cerebellum is involved in the generation of a motor-to-auditory forward model, patients with focal cerebellar lesions should not display an N100 suppression effect. Compared with healthy controls, patients showed a largely attenuated N100 suppression effect. The current results suggest that the cerebellum forms not only motor-to-somatosensory predictions but also motor-to-auditory predictions. This extends the cerebellar forward model to other sensory domains such as audition.

Original languageEnglish
Pages (from-to)698-706
Number of pages9
JournalJournal of Cognitive Neuroscience
Volume24
Issue number3
DOIs
Publication statusPublished - Mar 2012
MoE publication typeA1 Journal article-refereed

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