Templating Effects in the Dynamic Chemistry of Cucurbiturils and Hemicucurbiturils

Sandra Kaabel, Riina Aav*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

13 Citations (Scopus)


This review concentrates on the remarkable macrocyclisation chemistry of cucurbituril family members. During a single step in the condensation reaction of cucurbit[6]uril or hemicucurbit[12]uril 24 new C−N bonds are formed. In the case of hemicucurbit[12]uril this leads to the highly efficient formation of a covalently bound chain of 48 atoms. This phenomenon is possible because all cucurbiturils are built up of dynamic covalent acylaminal linkers. Moreover, the reversibility of acylaminal linkages makes the formation of macrocycles susceptible to external stimuli. Influence of the chain-growth and chain-cycle equilibrium and the effect of different templates in CB chemistry is discussed. As anions have a pronounced effect on formation of hemicucurbiturils, a comprehensive overview on their role in modifying the solid-state structures of hemicucurbiturils is given.

Original languageEnglish
Pages (from-to)296-313
Number of pages18
Issue number3
Publication statusPublished - Apr 2018
MoE publication typeA2 Review article in a scientific journal


  • crystal structure
  • cucurbituril
  • dynamic covalent chemistry
  • inclusion complexes
  • template


Dive into the research topics of 'Templating Effects in the Dynamic Chemistry of Cucurbiturils and Hemicucurbiturils'. Together they form a unique fingerprint.

Cite this