Tailored lignin-protein heteroconjugates for bionanomaterial applications

Maija-Liisa Mattinen, Monika Österberg, Juan Jose Valle-Delgado, Timo Leskinen, Miikka Lievonen, Tuomas Anttila

    Research output: Chapter in Book/Report/Conference proceedingConference contributionProfessional


    Bioindustry produces various side-streams such as lignin and proteins. Thus technologies for formation of stabile lignin nanodispersions using proteins as modifier, is a research goal that has world-wide significance for production of novel nanobiomaterials such as medical adhesives for biological tissues. Tailored lignin-protein heteroconjugates may be exploited also in textiles and cosmetics as well to improve e.g. antioxidative, -microbial and hydrophobic properties of the products. Small recombinant protein such as cellulose binding domain of cellulase will be used as biomimetic model to tailor lignin-protein heteroconjugates via self-assembling. Oxidative enzymes, protein engineering and chemical synthesis will be exploited to enhance interaction between proteins and lignin surface e.g. via introducing functionalities common in mussel mimetic glues. Interactions will be studied on molecular and functional group level using the state-of the art spectroscopic and microscopic techniques including rheological measurements. When protein stabilized lignin nanoparticles are applied in wounds and cross-linked by enzymatic means, protein gel containing softened lignin particles is formed and covalently linked to tissues, filling the wounds and ensuring tight water resistant sealing. Due to positive healthy effects of lignin wound healing will be fastened as viral and inflammatory risks are reduced.
    Original languageEnglish
    Title of host publication251st ACS, National Meeting and Exposition. CELL 226, Division of Cellulose and Renewable Materials, Lignin Refining, Functionalization & Utilization
    Publication statusPublished - 2015
    MoE publication typeD3 Professional conference proceedings
    EventAmerican Chemical Society National Meeting & Exposition - San Diego, United States
    Duration: 13 Mar 201617 Mar 2016
    Conference number: 251


    ConferenceAmerican Chemical Society National Meeting & Exposition
    Abbreviated titleACS
    Country/TerritoryUnited States
    CitySan Diego


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