System network biology approaches in exploring of mechanism behind mutagenesis

Anukriti, Swati Uniyal, Anupam Dhasmana*, Meenu Gupta, Kavindra Kumar Kesari, Qazi Mohd Sajid Jamal, Mohtashim Lohani

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Mutagenesis is the alteration of the genetic material by the help of mutagens. Mutations that are capable of inducing any diseases have a large impact on the biological systems. Whenever mutation occurs, it not only affects any particular gene or protein, but also affects the whole system related to that gene. Changes in one system will further bring out changes in the adjacent systems, which works in coordination with the mutated system. Thus, a single mutation can have an impact on more than one system. System network biology helps in providing a new perspective of inspection of these biological systems in the form of networks with the help of mathematical representations. In this chapter, we deal with different properties of the networks that help in analyzing the network-graph and finding the most probable network that best describes the process. Here we tried to investigate the candidate protein molecule that may act as a target protein with the help of network analysis. For this, we used various datasets and software that would be used in the reconstruction of different biological networks and pathways.

Original languageEnglish
Title of host publicationNetworking of Mutagens in Environmental Toxicology
Pages117-136
Number of pages20
ISBN (Electronic)978-3-319-96511-6
DOIs
Publication statusPublished - 1 Jan 2019
MoE publication typeA3 Part of a book or another research book

Publication series

NameEnvironmental Science and Engineering
PublisherSpringer
ISSN (Print)1863-5520
ISSN (Electronic)1863-5539

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