A convergent synthesis of biosynthetic precursors of brassinosteroids - secasterol and 24-episecasterol with Δ2-bond in cycle A is described. The key stages in the construction of the side chain of these compounds were Julia olefination of steroid 22-aldehyde followed by asymmetric Sharpless dihydroxylation of the intermediate Δ22-olefin. Toxicity of synthesized compounds against breast carcinoma MCF-7 cells was studied.
|Number of pages||10|
|Publication status||Published - 1 Nov 2010|
|MoE publication type||A1 Journal article-refereed|