[Synthesis of secasterol and 24-episecasterol and their toxicity in MCF-7 cells].

V. A. Khripach*, V. N. Zhabinskiǐ, O. V. Gyliakevich, O. V. Konstantinova, A. I. Misharin, A. R. Mekhtiev, V. P. Timofeev, I. V. Tkachev

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

A convergent synthesis of biosynthetic precursors of brassinosteroids - secasterol and 24-episecasterol with Δ2-bond in cycle A is described. The key stages in the construction of the side chain of these compounds were Julia olefination of steroid 22-aldehyde followed by asymmetric Sharpless dihydroxylation of the intermediate Δ22-olefin. Toxicity of synthesized compounds against breast carcinoma MCF-7 cells was studied.

Original languageEnglish
Pages (from-to)815-824
Number of pages10
JournalBioorganicheskaia khimiia
Volume36
Issue number6
Publication statusPublished - 1 Nov 2010
MoE publication typeA1 Journal article-refereed

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