Synthesis of sandwich-structured silver@polydopamine@silver shells with enhanced antibacterial activities

Bin Shang, Miao Xu, Zelun Zhi, Yuewei Xi, Yanbing Wang, Bo Peng*, Peng Li, Ziwei Deng

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

14 Citations (Scopus)
9 Downloads (Pure)


The unique antibacterial characteristics of Ag nanomaterials offer a wide potential range of applications, but achieving rapid and durable antibacterial efficacy is challenging. This is because the speed and durability of the antibacterial function make conflicting demands on the structural design: the former requires the direct exposure of Ag to the surrounding environment, whereas the durability requires Ag to be protected from the environment. To overcome this incompatibility, we synthesize sandwich-structured polydopamine shells decorated both internally and externally with Ag nanoparticles, which exhibit prompt and lasting bioactivity in applications. These shells are biocompatible and can be used in vivo to counter bacterial infection caused by methicillin-resistant Staphylococcus aureus superbugs and to inhibit biofilm formation. This work represents a new paradigm for the design of composite materials with enhanced antibacterial properties.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalJournal of Colloid and Interface Science
Publication statusPublished - 15 Dec 2019
MoE publication typeA1 Journal article-refereed


  • Ag nanoparticles
  • Antibacterial activity
  • Nanocomposite shells
  • Polydopamine
  • Sandwich structure


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