Synthesis of deuterium-labeled (24R)-methyl brassinosteroids

Vladimir A. Khripach; Vladimir N. Zhabinskii; Olga V. Gulyakevich; Yurii V. Ermolovich; Olga V. Konstantinova

doi:10.1002/jlcr.1874

Synthesis of deuterium-labeled (24R)-methyl brassinosteroids

Vladimir A. Khripach, Vladimir N. Zhabinskii, Olga V. Gulyakevich, Yurii V. Ermolovich, Olga V. Konstantinova

Not published at Aalto University

National Academy of Sciences of Belarus

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Abstract

Synthesis of labeled brassinosteroids (24-epibrassinolide and its biosynthetic precursors) containing three deuterium atoms in the terminal part of the side chain is reported. Labeling was achieved by three-step reductive transformation of carbethoxy group into methyl using lithium aluminium deuteride. The proposed method ensured high isotopic purity of (24R)-methyl brassinosteroids containing a label in a position which is not subjected to its loss.

Original language	English
Pages (from-to)	332-336
Number of pages	5
Journal	JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS
Volume	54
Issue number	6
DOIs	https://doi.org/10.1002/jlcr.1874
Publication status	Published - 30 May 2011
MoE publication type	A1 Journal article-refereed

Keywords

brassinosteroids
epibrassinolide
epicastasterone
episecasterol
episecasterone

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10.1002/jlcr.1874

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title = "Synthesis of deuterium-labeled (24R)-methyl brassinosteroids",

abstract = "Synthesis of labeled brassinosteroids (24-epibrassinolide and its biosynthetic precursors) containing three deuterium atoms in the terminal part of the side chain is reported. Labeling was achieved by three-step reductive transformation of carbethoxy group into methyl using lithium aluminium deuteride. The proposed method ensured high isotopic purity of (24R)-methyl brassinosteroids containing a label in a position which is not subjected to its loss.",

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AU - Khripach, Vladimir A.

AU - Zhabinskii, Vladimir N.

AU - Gulyakevich, Olga V.

AU - Ermolovich, Yurii V.

AU - Konstantinova, Olga V.

PY - 2011/5/30

Y1 - 2011/5/30

N2 - Synthesis of labeled brassinosteroids (24-epibrassinolide and its biosynthetic precursors) containing three deuterium atoms in the terminal part of the side chain is reported. Labeling was achieved by three-step reductive transformation of carbethoxy group into methyl using lithium aluminium deuteride. The proposed method ensured high isotopic purity of (24R)-methyl brassinosteroids containing a label in a position which is not subjected to its loss.

AB - Synthesis of labeled brassinosteroids (24-epibrassinolide and its biosynthetic precursors) containing three deuterium atoms in the terminal part of the side chain is reported. Labeling was achieved by three-step reductive transformation of carbethoxy group into methyl using lithium aluminium deuteride. The proposed method ensured high isotopic purity of (24R)-methyl brassinosteroids containing a label in a position which is not subjected to its loss.

KW - brassinosteroids

KW - epibrassinolide

KW - epicastasterone

KW - episecasterol

KW - episecasterone

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JO - JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS

JF - JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS

SN - 0362-4803

IS - 6

ER -

Synthesis of deuterium-labeled (24R)-methyl brassinosteroids

Abstract

Keywords

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