Synthesis of labeled brassinosteroids (24-epibrassinolide and its biosynthetic precursors) containing three deuterium atoms in the terminal part of the side chain is reported. Labeling was achieved by three-step reductive transformation of carbethoxy group into methyl using lithium aluminium deuteride. The proposed method ensured high isotopic purity of (24R)-methyl brassinosteroids containing a label in a position which is not subjected to its loss.
|Number of pages||5|
|Journal||JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS|
|Publication status||Published - 30 May 2011|
|MoE publication type||A1 Journal article-refereed|