Synthesis of deuterium-labeled (24R)-methyl brassinosteroids

Vladimir A. Khripach, Vladimir N. Zhabinskii, Olga V. Gulyakevich, Yurii V. Ermolovich, Olga V. Konstantinova

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)

Abstract

Synthesis of labeled brassinosteroids (24-epibrassinolide and its biosynthetic precursors) containing three deuterium atoms in the terminal part of the side chain is reported. Labeling was achieved by three-step reductive transformation of carbethoxy group into methyl using lithium aluminium deuteride. The proposed method ensured high isotopic purity of (24R)-methyl brassinosteroids containing a label in a position which is not subjected to its loss.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
JournalJOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS
Volume54
Issue number6
DOIs
Publication statusPublished - 30 May 2011
MoE publication typeA1 Journal article-refereed

Keywords

  • brassinosteroids
  • epibrassinolide
  • epicastasterone
  • episecasterol
  • episecasterone

Fingerprint Dive into the research topics of 'Synthesis of deuterium-labeled (24R)-methyl brassinosteroids'. Together they form a unique fingerprint.

Cite this