Synthesis and in vitro evaluation of novel tetralin-pyrazolo[3,4-b]pyridine hybrids as potential anticancer agents

Research output: Contribution to journalArticle

Researchers

  • Eman Kh Hamza
  • Nehal A. Hamdy
  • Eman S. Zarie
  • Issa M. I. Fakhr
  • Ahmed H. M. Elwahy
  • Hanem M. Awad

Research units

  • National Research Center
  • Cairo University

Abstract

New hybrids of tetralin-pyrazolo[3,4-b]pyridine were synthesized in good yields. The structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental analyses. Some of the new compounds were in vitro evaluated as antiproliferative candidates against two human cancer cell lines (HCT116 and MCF-7). Most of the examined derivatives showed promising anticancer activity.

Details

Original languageEnglish
Number of pages15
JournalJOURNAL OF HETEROCYCLIC CHEMISTRY
Publication statusPublished - 19 Nov 2019
MoE publication typeA1 Journal article-refereed

    Research areas

  • BIOLOGICAL EVALUATION, PYRIDINE-DERIVATIVES, ANALGESIC ACTIVITY, DESIGN, PIM-1, INHIBITORS, CHEMISTRY, DISCOVERY, MOIETY

ID: 39157651