Synthesis and in vitro evaluation of novel tetralin-pyrazolo[3,4-b]pyridine hybrids as potential anticancer agents

Eman Kh Hamza, Nehal A. Hamdy*, Eman S. Zarie, Issa M. I. Fakhr, Ahmed H. M. Elwahy, Hanem M. Awad

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

New hybrids of tetralin-pyrazolo[3,4-b]pyridine were synthesized in good yields. The structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental analyses. Some of the new compounds were in vitro evaluated as antiproliferative candidates against two human cancer cell lines (HCT116 and MCF-7). Most of the examined derivatives showed promising anticancer activity.

Original languageEnglish
Number of pages15
JournalJOURNAL OF HETEROCYCLIC CHEMISTRY
DOIs
Publication statusPublished - 19 Nov 2019
MoE publication typeA1 Journal article-refereed

Keywords

  • BIOLOGICAL EVALUATION
  • PYRIDINE-DERIVATIVES
  • ANALGESIC ACTIVITY
  • DESIGN
  • PIM-1
  • INHIBITORS
  • CHEMISTRY
  • DISCOVERY
  • MOIETY

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