Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

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Abstract

A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.

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Original languageEnglish
Pages (from-to)4441-4447
JournalBIOORGANIC AND MEDICINAL CHEMISTRY
Volume17
Issue number13
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

    Research areas

  • cannabinoid, receptor CB2, quinoline, isoquinoline

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