Abstract
A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.
Original language | English |
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Pages (from-to) | 4441-4447 |
Journal | BIOORGANIC AND MEDICINAL CHEMISTRY |
Volume | 17 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2009 |
MoE publication type | A1 Journal article-refereed |
Keywords
- cannabinoid
- receptor CB2
- quinoline
- isoquinoline