TY - JOUR
T1 - SynergyFinder 2.0: Visual analytics of multi-drug combination synergies
AU - Ianevski, Aleksandr
AU - Giri, Anil K.
AU - Aittokallio, Tero
N1 - Funding Information:
Academy of Finland [292611, 310507, 313267, 326238 to T.A.]; Cancer Society of Finland [to T.A.]; Sigrid Jus?lius Foundation [to TA]. Funding for open access charge: European Union's Horizon 2020 Research and Innovation Programme [ERA PerMed JAKSTAT-TARGET project].
Funding Information:
Academy of Finland [292611, 310507, 313267, 326238 to T.A.]; Cancer Society of Finland [to T.A.]; Sigrid Jusélius Foundation [to TA]. Funding for open access charge: European Union’s Horizon 2020 Research and Innovation Programme [ERA PerMed JAKSTAT-TARGET project]. Conflict of interest statement. None declared.
Publisher Copyright:
© The Author(s) 2020.
PY - 2021
Y1 - 2021
N2 - SynergyFinder (https://synergyfinder.fimm.fi) is a stand-alone web-application for interactive analysis and visualization of drug combination screening data. Since its first release in 2017, SynergyFinder has become a widely used web-tool both for the discovery of novel synergistic drug combinations in pre-clinical model systems (e.g. cell lines or primary patient-derived cells), and for better understanding of mechanisms of combination treatment efficacy or resistance. Here, we describe the latest version of SynergyFinder (release 2.0), which has extensively been upgraded through the addition of novel features supporting especially higher-order combination data analytics and exploratory visualization of multi-drug synergy patterns, along with automated outlier detection procedure, extended curve-fitting functionality and statistical analysis of replicate measurements. A number of additional improvements were also implemented based on the user requests, including new visualization and export options, updated user interface, as well as enhanced stability and performance of the web-tool. With these improvements, SynergyFinder 2.0 is expected to greatly extend its potential applications in various areas of multi-drug combinatorial screening and precision medicine.
AB - SynergyFinder (https://synergyfinder.fimm.fi) is a stand-alone web-application for interactive analysis and visualization of drug combination screening data. Since its first release in 2017, SynergyFinder has become a widely used web-tool both for the discovery of novel synergistic drug combinations in pre-clinical model systems (e.g. cell lines or primary patient-derived cells), and for better understanding of mechanisms of combination treatment efficacy or resistance. Here, we describe the latest version of SynergyFinder (release 2.0), which has extensively been upgraded through the addition of novel features supporting especially higher-order combination data analytics and exploratory visualization of multi-drug synergy patterns, along with automated outlier detection procedure, extended curve-fitting functionality and statistical analysis of replicate measurements. A number of additional improvements were also implemented based on the user requests, including new visualization and export options, updated user interface, as well as enhanced stability and performance of the web-tool. With these improvements, SynergyFinder 2.0 is expected to greatly extend its potential applications in various areas of multi-drug combinatorial screening and precision medicine.
UR - http://www.scopus.com/inward/record.url?scp=85086923971&partnerID=8YFLogxK
U2 - 10.1093/NAR/GKAA216
DO - 10.1093/NAR/GKAA216
M3 - Article
C2 - 32246720
AN - SCOPUS:85086923971
SN - 0305-1048
VL - 48
SP - W488-W493
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - 1
ER -