We propose a definition of symbiotic interaction that is informed by current developments in computing. We clearly distinguish this definition from previous ones and from selected paradigms that address the human-computer relationship. The definition is also informed by a variety of human-centered frameworks in human-computer interaction, including embodied interactions, situationist frameworks, and participatory and work-oriented design perspectives. Symbiotic interactions can be achieved by combining computation, sensing technology, and interaction design to realize deep perception, awareness, and understanding between humans and computers. Important aspects to implement are transparency, reciprocity, and collaborative use of resources for both computers and humans. The symbiotic relationship is also characterized by goals and agency independence of humans and computers. The definition sets the premise to discuss in a critical way future research agendas for symbiotic interactions that are sensitive to human-centered values.