Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles

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Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles. / Viitala, Lauri; Maley, Adam; Fung, Millie; Corn, Robert; Viitala, Tapani; Murtomäki, Lasse.

In: Journal of Physical Chemistry C, Vol. 120, 31.10.2016, p. 25958−25966.

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Viitala, Lauri ; Maley, Adam ; Fung, Millie ; Corn, Robert ; Viitala, Tapani ; Murtomäki, Lasse. / Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles. In: Journal of Physical Chemistry C. 2016 ; Vol. 120. pp. 25958−25966.

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@article{b8258ed3ae4e4400938cbe2915cc77b0,
title = "Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles",
abstract = "Liposomes are small vesicles that can be used in various targeting applications as carrier vehicles. In this paper, we show that realtime surface plasmon resonance imaging microscopy (SPRI microscopy) can be used to detect diffraction patterns of these singular vesicles in water phase at room temperature and without any additives. The diffraction pattern intensities, related to the particle size, are shown to follow the lognormal distribution in a cumulative distribution function (CDF) that is very well in accordance with the normal size distribution of liposomes prepared with the extrusion method. In addition, this distribution is further analyzed to determine the number of gold nanoparticle (GNP) encapsulated liposomes in a set of liposomal adsorption events. Thus, we obtain the encapsulation efficiency and present a method to study the intrinsic properties of liposomes and other soft nanomaterials.",
keywords = "Liposome, drug delivery systems, surface plasmon resonance, gold nanoparticle",
author = "Lauri Viitala and Adam Maley and Millie Fung and Robert Corn and Tapani Viitala and Lasse Murtom{\"a}ki",
year = "2016",
month = "10",
day = "31",
doi = "10.1021/acs.jpcc.6b09503",
language = "English",
volume = "120",
pages = "25958−25966",
journal = "Journal of Physical Chemistry C",
issn = "1932-7447",
publisher = "AMERICAN CHEMICAL SOCIETY",

}

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TY - JOUR

T1 - Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles

AU - Viitala, Lauri

AU - Maley, Adam

AU - Fung, Millie

AU - Corn, Robert

AU - Viitala, Tapani

AU - Murtomäki, Lasse

PY - 2016/10/31

Y1 - 2016/10/31

N2 - Liposomes are small vesicles that can be used in various targeting applications as carrier vehicles. In this paper, we show that realtime surface plasmon resonance imaging microscopy (SPRI microscopy) can be used to detect diffraction patterns of these singular vesicles in water phase at room temperature and without any additives. The diffraction pattern intensities, related to the particle size, are shown to follow the lognormal distribution in a cumulative distribution function (CDF) that is very well in accordance with the normal size distribution of liposomes prepared with the extrusion method. In addition, this distribution is further analyzed to determine the number of gold nanoparticle (GNP) encapsulated liposomes in a set of liposomal adsorption events. Thus, we obtain the encapsulation efficiency and present a method to study the intrinsic properties of liposomes and other soft nanomaterials.

AB - Liposomes are small vesicles that can be used in various targeting applications as carrier vehicles. In this paper, we show that realtime surface plasmon resonance imaging microscopy (SPRI microscopy) can be used to detect diffraction patterns of these singular vesicles in water phase at room temperature and without any additives. The diffraction pattern intensities, related to the particle size, are shown to follow the lognormal distribution in a cumulative distribution function (CDF) that is very well in accordance with the normal size distribution of liposomes prepared with the extrusion method. In addition, this distribution is further analyzed to determine the number of gold nanoparticle (GNP) encapsulated liposomes in a set of liposomal adsorption events. Thus, we obtain the encapsulation efficiency and present a method to study the intrinsic properties of liposomes and other soft nanomaterials.

KW - Liposome

KW - drug delivery systems

KW - surface plasmon resonance

KW - gold nanoparticle

U2 - 10.1021/acs.jpcc.6b09503

DO - 10.1021/acs.jpcc.6b09503

M3 - Article

VL - 120

SP - 25958−25966

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

SN - 1932-7447

ER -

ID: 10970585