Surface Modification of Bioactive Glass Promotes Cell Attachment and Spreading

Latifeh Azizi, Paula Turkki, Ngoc Huynh, Jonathan M. Massera, Vesa P. Hytönen*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)


Phosphate glasses have several advantages over traditional silicate-based bioglasses but are inferior in the crucial step of cell attachment to their surface. Here, as a proof of concept, we analyze fibroblast attachment to the phosphate glass surface subjected to basic treatment and silanization. Silicate (S53P4)- and phosphate (Sr50)-based bioactive glasses were either untreated or surface-treated with basic buffer and functionalized with silane. The surface-treated samples were studied as such and after fibronectin was adsorbed on to their surface. With both glass types, surface treatment enhanced fibroblast adhesion and spreading in comparison to the untreated glass. The surface-treated Sr50 glass allowed for cell adhesion, proliferation, and spreading to a similar extent as seen with S53P4 and borosilicate control glasses. Here, we show that surface treatment of bioactive glass can be used to attract cell adhesion factors found in the serum and promote cell-material adhesion, both important for efficient tissue integration.
Original languageEnglish
Pages (from-to)22635-22642
Number of pages8
JournalACS Omega
Issue number35
Early online date25 Aug 2021
Publication statusPublished - 7 Sept 2021
MoE publication typeA1 Journal article-refereed


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