Superhydrophobic blood-repellent surfaces

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Superhydrophobic blood-repellent surfaces. / Jokinen, Ville; Kankuri, Esko; Hoshian, Sasha; Franssila, Sami; Ras, Robin.

In: Advanced Materials, Vol. 30, No. 24, 1705104, 06.2018.

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@article{56a7db5142e34943ba9128bc847ab908,
title = "Superhydrophobic blood-repellent surfaces",
abstract = "Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water- and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted.",
keywords = "antithrombogenic, blood-compatible, blood-repellent, nanostructures, superhydrophobic",
author = "Ville Jokinen and Esko Kankuri and Sasha Hoshian and Sami Franssila and Robin Ras",
note = "| openaire: EC/H2020/725513/EU//SuperRepel",
year = "2018",
month = "6",
doi = "10.1002/adma.201705104",
language = "English",
volume = "30",
journal = "Advanced Materials",
issn = "0935-9648",
number = "24",

}

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TY - JOUR

T1 - Superhydrophobic blood-repellent surfaces

AU - Jokinen, Ville

AU - Kankuri, Esko

AU - Hoshian, Sasha

AU - Franssila, Sami

AU - Ras, Robin

N1 - | openaire: EC/H2020/725513/EU//SuperRepel

PY - 2018/6

Y1 - 2018/6

N2 - Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water- and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted.

AB - Superhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water- and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted.

KW - antithrombogenic

KW - blood-compatible

KW - blood-repellent

KW - nanostructures

KW - superhydrophobic

U2 - 10.1002/adma.201705104

DO - 10.1002/adma.201705104

M3 - Letter

VL - 30

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 24

M1 - 1705104

ER -

ID: 18032831