Submillimeter-wave imaging assisted alignment of millimeter-wave spectroscopic system for quantification of corneal water content

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Abstract

We propose an alignment strategy for millimeter spectroscopy of cornea that uses imaging to screen for sufficient alignment conditions. The performance of different corneal imaging objectives, in the presence of misalignment, is evaluated. The cornea is illuminated with a TEM00 Gaussian beam at 650 GHz and the beam is swept across the cornea. Images are generated by calculating the coupling between illumination and scattered beams for each illumination beam position and angle. The cornea is displaced at intervals of 500 microns in the transverse and axial directions and with new coupling coefficient maps generated at each misaligned position. Contrast in the misaligned cases are compared to the aligned case via zero normalized spatial cross correlation. The results show a maximum normalized cross correlation of 0.92 for a two-mirror scanning system and 0.74 for a one-mirror scanning objective. The analysis suggests that imaging contrast at 650 GHz can be used to screen for misalignment that would be difficult to detect with MMW.

Original languageEnglish
Title of host publicationSPIE Conference Proceedings
EditorsMona Jarrahi, Sascha Preu, Dmitry Turchinovich
ISBN (Electronic)9781510634688
DOIs
Publication statusPublished - 1 Jan 2020
MoE publication typeA4 Article in a conference publication
EventSPIE Photonics Europe: Terahertz Photonics - , France
Duration: 6 Apr 202010 Apr 2020

Publication series

NameProceedings of SPIE : the International Society for Optical Engineering
Volume11348
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceSPIE Photonics Europe
CountryFrance
Period06/04/202010/04/2020

Keywords

  • Cornea
  • medical imaging
  • physical optics
  • quasioptics
  • submillimeter wave remote sensing
  • THz
  • THz imaging

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  • Cite this

    Baggio, M., Hu, Y., Tamminen, A., Nefedova, I., Ala-Laurinaho, J., & Taylor, Z. (2020). Submillimeter-wave imaging assisted alignment of millimeter-wave spectroscopic system for quantification of corneal water content. In M. Jarrahi, S. Preu, & D. Turchinovich (Eds.), SPIE Conference Proceedings [113480M] (Proceedings of SPIE : the International Society for Optical Engineering; Vol. 11348). https://doi.org/10.1117/12.2556309