Studying the Sensitivity of Graphene for Biosensor Applications

A. S. Usikov; S. P. Lebedev; A. D. Roenkov; I. S. Barash; S. Novikov; M. Puzyk; A. Zubov; Yu N. Makarov; A. A. Lebedev

doi:10.1134/S1063785020050296

Studying the Sensitivity of Graphene for Biosensor Applications

A. S. Usikov^*, S. P. Lebedev, A. D. Roenkov, I. S. Barash, S. Novikov, M. Puzyk, A. Zubov, Yu N. Makarov, A. A. Lebedev

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

We have studied the response of graphene-film-based chips on SiC substrates (the relative change in the chip resistance) to coming into contact with fluorescein (C20H12O5) in a wide range of its concentrations in a phosphate-buffered saline solution: from 1 x 10(-3)to 1 x 10(4)ng/mL (seven orders of magnitude). Fluorescein detection seems to be a simple and cheap model experiment to study the sensory ability of graphene in the way of biochips manufacturing. It has been shown that chips with wide terraces on a surface with a step width of about 1000 nm and heights of up to 5 nm made it possible to construct the calibration dependences of chip response on fluorescein concentration.

Original language	English
Pages (from-to)	462-465
Number of pages	4
Journal	Technical Physics Letters
Volume	46
Issue number	5
DOIs	https://doi.org/10.1134/S1063785020050296
Publication status	Published - May 2020
MoE publication type	A1 Journal article-refereed

Keywords

graphene
silicon carbide
biosensor
fluorescein

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title = "Studying the Sensitivity of Graphene for Biosensor Applications",

abstract = "We have studied the response of graphene-film-based chips on SiC substrates (the relative change in the chip resistance) to coming into contact with fluorescein (C20H12O5) in a wide range of its concentrations in a phosphate-buffered saline solution: from 1 x 10(-3)to 1 x 10(4)ng/mL (seven orders of magnitude). Fluorescein detection seems to be a simple and cheap model experiment to study the sensory ability of graphene in the way of biochips manufacturing. It has been shown that chips with wide terraces on a surface with a step width of about 1000 nm and heights of up to 5 nm made it possible to construct the calibration dependences of chip response on fluorescein concentration.",

keywords = "graphene, silicon carbide, biosensor, fluorescein",

author = "Usikov, {A. S.} and Lebedev, {S. P.} and Roenkov, {A. D.} and Barash, {I. S.} and S. Novikov and M. Puzyk and A. Zubov and Makarov, {Yu N.} and Lebedev, {A. A.}",

year = "2020",

month = may,

doi = "10.1134/S1063785020050296",

language = "English",

volume = "46",

pages = "462--465",

journal = "Technical Physics Letters",

issn = "1063-7850",

publisher = "Pleiades Publishing",

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TY - JOUR

T1 - Studying the Sensitivity of Graphene for Biosensor Applications

AU - Usikov, A. S.

AU - Lebedev, S. P.

AU - Roenkov, A. D.

AU - Barash, I. S.

AU - Novikov, S.

AU - Puzyk, M.

AU - Zubov, A.

AU - Makarov, Yu N.

AU - Lebedev, A. A.

PY - 2020/5

Y1 - 2020/5

N2 - We have studied the response of graphene-film-based chips on SiC substrates (the relative change in the chip resistance) to coming into contact with fluorescein (C20H12O5) in a wide range of its concentrations in a phosphate-buffered saline solution: from 1 x 10(-3)to 1 x 10(4)ng/mL (seven orders of magnitude). Fluorescein detection seems to be a simple and cheap model experiment to study the sensory ability of graphene in the way of biochips manufacturing. It has been shown that chips with wide terraces on a surface with a step width of about 1000 nm and heights of up to 5 nm made it possible to construct the calibration dependences of chip response on fluorescein concentration.

AB - We have studied the response of graphene-film-based chips on SiC substrates (the relative change in the chip resistance) to coming into contact with fluorescein (C20H12O5) in a wide range of its concentrations in a phosphate-buffered saline solution: from 1 x 10(-3)to 1 x 10(4)ng/mL (seven orders of magnitude). Fluorescein detection seems to be a simple and cheap model experiment to study the sensory ability of graphene in the way of biochips manufacturing. It has been shown that chips with wide terraces on a surface with a step width of about 1000 nm and heights of up to 5 nm made it possible to construct the calibration dependences of chip response on fluorescein concentration.

KW - graphene

KW - silicon carbide

KW - biosensor

KW - fluorescein

U2 - 10.1134/S1063785020050296

DO - 10.1134/S1063785020050296

M3 - Article

SN - 1063-7850

VL - 46

SP - 462

EP - 465

JO - Technical Physics Letters

JF - Technical Physics Letters

IS - 5

ER -

Studying the Sensitivity of Graphene for Biosensor Applications

Abstract

Keywords

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