State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches

Natural hydrogel-based wound dressings, synthesized from biopolymers such as chitosan, sodium alginate, and cellulose, are gaining recognition in wound care due to their ability to promote healing through biocompatibility, moisture retention, and biodegradability. These materials foster an ideal healing environment by supporting cell proliferation and tissue regeneration while providing a protective barrier against infection. For chronic or infected wounds, enhancing the therapeutic performance of these hydrogels is essential. This review critically evaluates advanced functionalization strategies, including chemical modifications to optimize hydrogel properties, the incorporation of bioactive agents like growth factors and antimicrobial compounds, and the development of stimuli-responsive hydrogels that adjust to environmental cues such as pH, temperature, and enzymatic activity. Furthermore, fabrication techniques—such as solution casting, freeze-drying, electrospinning, and 3D printing—are discussed for their potential to generate tailored dressings with specific mechanical properties and bioactive capabilities. By highlighting key innovations and challenges, this review provides a comprehensive roadmap for the design, functionalization, and fabrication of natural hydrogel-based wound dressings, identifying critical areas for future research and development.