Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy

Research output: Contribution to journalReview ArticleScientificpeer-review

Researchers

Research units

  • Amity University Uttar Pradesh
  • Texas Tech University Health Sciences Center
  • Novel Global Community Educational Foundation
  • Indian Institute of Technology Mandi

Abstract

Nanotechnology has been the latest approach for diagnosis and treatment of cancer, which opens up a new alternative therapeutic drug delivery option to treat disease. Nanoparticles (NPs) display a broad role in cancer diagnosis and has various advantages over the other conventional chemotherapeutic drug delivery. NPs possess more specific and efficient drug delivery to the targeted tissue, cell, or organs and minimize the risk of side effects. NPs undergo passive and active mode of drug targets to the tumor area with less elimination of the drug from the system. Size and surface characteristics of nanoparticles play a crucial role in modulating nanocarrier efficiency and the biodistribution of chemo drugs in the body. Several types of nanocarriers, such as polymers, dendrimers, liposome-based, and carbon-based, are studied widely in cancer therapy. Although FDA approved very few nanotechnology drugs for cancer therapy, a large number of studies are undergoing for the development of novel nanocarriers for potent cancer therapy. In this review, we discuss details of the nano-based therapeutics and diagnostics strategies, and the potential use of nanomedicines in cancer drug delivery and cancer therapy.

Details

Original languageEnglish
JournalSEMINARS IN CANCER BIOLOGY
Publication statusE-pub ahead of print - 2019
MoE publication typeA2 Review article in a scientific journal

ID: 39045308