Smart Hydrogels for Advanced Drug Delivery Systems

Aydin Bordbar-Khiabani*, Michael Gasik

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

102 Citations (Scopus)
139 Downloads (Pure)


Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used in these systems due to their high stability, physicochemical properties, and biocompatibility. Smart hydrogels can change their hydrophilicity, swelling ability, physical properties, and molecules permeability, influenced by external stimuli such as pH, temperature, electrical and magnetic fields, light, and the biomolecules’ concentration, thus resulting in the controlled release of the loaded drugs. Herein, this review encompasses the latest investigations in the field of stimuli-responsive drug-loaded hydrogels and our contribution to this matter.

Original languageEnglish
Article number3665
Number of pages23
JournalInternational Journal of Molecular Sciences
Issue number7
Early online date27 Mar 2022
Publication statusPublished - 1 Apr 2022
MoE publication typeA2 Review article, Literature review, Systematic review


  • biomedicine
  • controlled release
  • drug delivery
  • drug-loaded hydrogels
  • smart hydrogels
  • stimuli-responsive hydrogels


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