Single-Walled Carbon Nanotube Network Electrodes for the Detection of Fentanyl Citrate

Niklas Wester; Elsi Mynttinen; Jarkko Etula; Tuomas Lilius; Eija Kalso; Bjørn F. Mikladal; Qiang Zhang; Hua Jiang; Sami Sainio; Dennis Nordlund; Esko I. Kauppinen; Tomi Laurila; Jari Koskinen

doi:10.1021/acsanm.9b01951

Single-Walled Carbon Nanotube Network Electrodes for the Detection of Fentanyl Citrate

Niklas Wester^*, Elsi Mynttinen, Jarkko Etula, Tuomas Lilius, Eija Kalso, Bjørn F. Mikladal, Qiang Zhang, Hua Jiang, Sami Sainio, Dennis Nordlund, Esko I. Kauppinen, Tomi Laurila, Jari Koskinen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

44 Citations (Scopus)

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Abstract

We prepare disposable single-walled carbon nanotube network electrodes for the detection of the potent opioid fentanyl, currently a leading cause for opioid overdose deaths in the USA. We show repeatable dry transfer of single-walled carbon nanotube (SWCNT) networks to produce robust electrodes. This process directly produces highly conductive SWCNT electrodes without the need for any further modifications required for conventional carbon electrodes. The realized electrode showed low background currents combined with spontaneous enrichment of fentanyl, resulting in a high signal-to-noise ratio. With this electrode, a detection limit of 11 nM and a linear range of 0.01-1 μM were found for fentanyl. In addition, selectivity is demonstrated in the presence of several common interferents.

Original language	English
Pages (from-to)	1203-1212
Number of pages	10
Journal	ACS Applied Nano Materials
Volume	3
Issue number	2
DOIs	https://doi.org/10.1021/acsanm.9b01951
Publication status	Published - 28 Feb 2020
MoE publication type	A1 Journal article-refereed

Funding

This work was supported by the Business Finland (FEDOC 211637 and FEPOD 2117731 projects). The authors acknowledge the provision of facilities by Aalto University Bioeconomy and Dr. Leena-Sisko Johansson for help with XPS analysis. The provisions of facilities of OtaNano are also acknowledged. Use of the Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, is supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract DE-AC02-76SF00515.

Keywords

DPV
electrochemical sensor
fentanyl citrate
SWCNT
voltammetry

Access to Document

10.1021/acsanm.9b01951Licence: CC BY

acsanm.9b01951-1Final published version, 4.35 MBLicence: CC BY

https://www.osti.gov/biblio/1617140

Cite this

@article{330fdcd3a2fb42afae373844384fc9a0,

title = "Single-Walled Carbon Nanotube Network Electrodes for the Detection of Fentanyl Citrate",

abstract = "We prepare disposable single-walled carbon nanotube network electrodes for the detection of the potent opioid fentanyl, currently a leading cause for opioid overdose deaths in the USA. We show repeatable dry transfer of single-walled carbon nanotube (SWCNT) networks to produce robust electrodes. This process directly produces highly conductive SWCNT electrodes without the need for any further modifications required for conventional carbon electrodes. The realized electrode showed low background currents combined with spontaneous enrichment of fentanyl, resulting in a high signal-to-noise ratio. With this electrode, a detection limit of 11 nM and a linear range of 0.01-1 μM were found for fentanyl. In addition, selectivity is demonstrated in the presence of several common interferents.",

keywords = "DPV, electrochemical sensor, fentanyl citrate, SWCNT, voltammetry",

author = "Niklas Wester and Elsi Mynttinen and Jarkko Etula and Tuomas Lilius and Eija Kalso and Mikladal, \{Bj{\o}rn F.\} and Qiang Zhang and Hua Jiang and Sami Sainio and Dennis Nordlund and Kauppinen, \{Esko I.\} and Tomi Laurila and Jari Koskinen",

year = "2020",

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doi = "10.1021/acsanm.9b01951",

language = "English",

volume = "3",

pages = "1203--1212",

journal = "ACS Applied Nano Materials",

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TY - JOUR

T1 - Single-Walled Carbon Nanotube Network Electrodes for the Detection of Fentanyl Citrate

AU - Wester, Niklas

AU - Mynttinen, Elsi

AU - Etula, Jarkko

AU - Lilius, Tuomas

AU - Kalso, Eija

AU - Mikladal, Bjørn F.

AU - Zhang, Qiang

AU - Jiang, Hua

AU - Sainio, Sami

AU - Nordlund, Dennis

AU - Kauppinen, Esko I.

AU - Laurila, Tomi

AU - Koskinen, Jari

PY - 2020/2/28

Y1 - 2020/2/28

N2 - We prepare disposable single-walled carbon nanotube network electrodes for the detection of the potent opioid fentanyl, currently a leading cause for opioid overdose deaths in the USA. We show repeatable dry transfer of single-walled carbon nanotube (SWCNT) networks to produce robust electrodes. This process directly produces highly conductive SWCNT electrodes without the need for any further modifications required for conventional carbon electrodes. The realized electrode showed low background currents combined with spontaneous enrichment of fentanyl, resulting in a high signal-to-noise ratio. With this electrode, a detection limit of 11 nM and a linear range of 0.01-1 μM were found for fentanyl. In addition, selectivity is demonstrated in the presence of several common interferents.

AB - We prepare disposable single-walled carbon nanotube network electrodes for the detection of the potent opioid fentanyl, currently a leading cause for opioid overdose deaths in the USA. We show repeatable dry transfer of single-walled carbon nanotube (SWCNT) networks to produce robust electrodes. This process directly produces highly conductive SWCNT electrodes without the need for any further modifications required for conventional carbon electrodes. The realized electrode showed low background currents combined with spontaneous enrichment of fentanyl, resulting in a high signal-to-noise ratio. With this electrode, a detection limit of 11 nM and a linear range of 0.01-1 μM were found for fentanyl. In addition, selectivity is demonstrated in the presence of several common interferents.

KW - DPV

KW - electrochemical sensor

KW - fentanyl citrate

KW - SWCNT

KW - voltammetry

UR - https://www.scopus.com/pages/publications/85078995993

U2 - 10.1021/acsanm.9b01951

DO - 10.1021/acsanm.9b01951

M3 - Article

AN - SCOPUS:85078995993

SN - 2574-0970

VL - 3

SP - 1203

EP - 1212

JO - ACS Applied Nano Materials

JF - ACS Applied Nano Materials

IS - 2

ER -

Single-Walled Carbon Nanotube Network Electrodes for the Detection of Fentanyl Citrate

Abstract

Funding

Keywords

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Fingerprint

FEPOD-TUTLI, T40218

FEDOC: Fast electrochemical detection of opioids in blood sample by carbon nano hybrid electrodes

Bioeconomy Research Infrastructure

OtaNano

OtaNano - Nanomicroscopy Center

Cite this

Single-Walled Carbon Nanotube Network Electrodes for the Detection of Fentanyl Citrate

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Projects

FEPOD-TUTLI, T40218

FEDOC: Fast electrochemical detection of opioids in blood sample by carbon nano hybrid electrodes

Equipment

Bioeconomy Research Infrastructure

OtaNano

OtaNano - Nanomicroscopy Center

Cite this