Simultaneous multi-slice inverse imaging of the human brain

Research output: Contribution to journalArticle


  • Yi Cheng Hsu
  • Ying Hua Chu
  • Shang Yueh Tsai
  • Wen Jui Kuo
  • Chun Yuan Chang
  • Fa-Hsuan Lin

Research units

  • National Taiwan University
  • National Chengchi University
  • National Yang-Ming University


Ultrafast functional magnetic resonance imaging (fMRI) can measure blood oxygen level dependent (BOLD) signals with high sensitivity and specificity. Here we propose a novel method: simultaneous multi-slice inverse imaging (SMS-InI) - a combination of simultaneous multi-slice excitation, simultaneous echo refocusing (SER), blipped controlled aliasing in parallel imaging echo-planar imaging (EPI), and regularized image reconstruction. Using a 32-channel head coil array on a 3 T scanner, SMS-InI achieves nominal isotropic 5-mm spatial resolution and 10 Hz sampling rate at the whole-brain level. Compared with traditional inverse imaging, we found that SMS-InI has higher spatial resolution with lower signal leakage and higher time-domain signal-to-noise ratio with the optimized regularization parameter in the reconstruction. SMS-InI achieved higher effective resolution and higher detection power in detecting visual cortex activity than InI. SMS-InI also detected subcortical fMRI signals with the similar sensitivity and localization accuracy like EPI. The spatiotemporal resolution of SMS-InI was used to reveal that presenting visual stimuli with 0.2 s latency between left and right visual hemifield led to 0.2 s relative hemodynamic response latency between the left and right visual cortices. Together, these results indicate that SMS-InI is a useful tool in measuring cortical and subcortical hemodynamic responses with high spatiotemporal resolution.


Original languageEnglish
Article number17019
Pages (from-to)1-13
JournalScientific Reports
Issue number1
Publication statusPublished - 1 Dec 2017
MoE publication typeA1 Journal article-refereed

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