Side-by-side 2D and 3D cell culturing microdevices for drug toxicity screening

Päivi Järvinen*, Ashkan Bonabi, Ville Jokinen, Tiina Sikanen

*Corresponding author for this work

Research output: Contribution to conferenceAbstractScientificpeer-review

Abstract

This work describes a microfluidic platform that enables simultaneous drug screening (here, paclitaxel) with cell monolayers (2D) and 3D cell spheroids in a single microchannel. Controlled overexposure of organically modified ceramics was exploited to create concave microwells of tunable size and shape by single-step lithography. Cell adherence was locally controlled by physico-chemical surface treatment to create cell-repellent microwells for spheroids and cell-adherent planar areas for cell monolayers.

Original languageEnglish
Pages754-755
Number of pages2
Publication statusPublished - 2019
MoE publication typeNot Eligible
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019
Conference number: 23

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleMicroTAS
CountrySwitzerland
CityBasel
Period27/10/201931/10/2019

Keywords

  • 3D cell culturing
  • Microwells
  • Organically modified ceramics
  • UV-lithography

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