Side-by-side 2D and 3D cell culturing microdevices for drug toxicity screening

Päivi Järvinen; Ashkan Bonabi; Ville Jokinen; Tiina Sikanen

Side-by-side 2D and 3D cell culturing microdevices for drug toxicity screening

Päivi Järvinen^*, Ashkan Bonabi, Ville Jokinen, Tiina Sikanen

^*Corresponding author for this work

Research output: Contribution to conference › Abstract › Scientific › peer-review

Abstract

This work describes a microfluidic platform that enables simultaneous drug screening (here, paclitaxel) with cell monolayers (2D) and 3D cell spheroids in a single microchannel. Controlled overexposure of organically modified ceramics was exploited to create concave microwells of tunable size and shape by single-step lithography. Cell adherence was locally controlled by physico-chemical surface treatment to create cell-repellent microwells for spheroids and cell-adherent planar areas for cell monolayers.

Original language	English
Pages	754-755
Number of pages	2
Publication status	Published - 2019
MoE publication type	Not Eligible
Event	International Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 Conference number: 23

Conference

Conference	International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated title	MicroTAS
Country/Territory	Switzerland
City	Basel
Period	27/10/2019 → 31/10/2019

Keywords

3D cell culturing
Microwells
Organically modified ceramics
UV-lithography

Cite this

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title = "Side-by-side 2D and 3D cell culturing microdevices for drug toxicity screening",

abstract = "This work describes a microfluidic platform that enables simultaneous drug screening (here, paclitaxel) with cell monolayers (2D) and 3D cell spheroids in a single microchannel. Controlled overexposure of organically modified ceramics was exploited to create concave microwells of tunable size and shape by single-step lithography. Cell adherence was locally controlled by physico-chemical surface treatment to create cell-repellent microwells for spheroids and cell-adherent planar areas for cell monolayers.",

keywords = "3D cell culturing, Microwells, Organically modified ceramics, UV-lithography",

author = "P{\"a}ivi J{\"a}rvinen and Ashkan Bonabi and Ville Jokinen and Tiina Sikanen",

year = "2019",

language = "English",

pages = "754--755",

note = "International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS ; Conference date: 27-10-2019 Through 31-10-2019",

}

TY - CONF

T1 - Side-by-side 2D and 3D cell culturing microdevices for drug toxicity screening

AU - Järvinen, Päivi

AU - Bonabi, Ashkan

AU - Jokinen, Ville

AU - Sikanen, Tiina

N1 - Conference code: 23

PY - 2019

Y1 - 2019

N2 - This work describes a microfluidic platform that enables simultaneous drug screening (here, paclitaxel) with cell monolayers (2D) and 3D cell spheroids in a single microchannel. Controlled overexposure of organically modified ceramics was exploited to create concave microwells of tunable size and shape by single-step lithography. Cell adherence was locally controlled by physico-chemical surface treatment to create cell-repellent microwells for spheroids and cell-adherent planar areas for cell monolayers.

AB - This work describes a microfluidic platform that enables simultaneous drug screening (here, paclitaxel) with cell monolayers (2D) and 3D cell spheroids in a single microchannel. Controlled overexposure of organically modified ceramics was exploited to create concave microwells of tunable size and shape by single-step lithography. Cell adherence was locally controlled by physico-chemical surface treatment to create cell-repellent microwells for spheroids and cell-adherent planar areas for cell monolayers.

KW - 3D cell culturing

KW - Microwells

KW - Organically modified ceramics

KW - UV-lithography

UR - http://www.scopus.com/inward/record.url?scp=85094975137&partnerID=8YFLogxK

M3 - Abstract

AN - SCOPUS:85094975137

SP - 754

EP - 755

T2 - International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 27 October 2019 through 31 October 2019

ER -

Side-by-side 2D and 3D cell culturing microdevices for drug toxicity screening

Abstract

Conference

Keywords

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