Short-interval intracortical inhibition in human primary motor cortex: A multi-locus transcranial magnetic stimulation study

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@article{600b1f04f3374d38a0894bf31bc18526,
title = "Short-interval intracortical inhibition in human primary motor cortex: A multi-locus transcranial magnetic stimulation study",
abstract = "Short-interval intracortical inhibition (SICI) has been studied with paired-pulse transcranial magnetic stimulation (TMS) by administering two pulses at a millisecond-scale interstimulus interval (ISI) to a single cortical target. It has, however, been difficult to study the interaction of nearby cortical targets with paired-pulse TMS. To overcome this limitation, we have developed a multi-locus TMS (mTMS) device, which allows controlling the stimulus location electronically. Here, we applied mTMS to study SICI in primary motor cortex with paired pulses targeted to adjacent locations, aiming to quantify the extent of the cortical region producing SICI in the location of a test stimulus. We varied the location and timing of the conditioning stimulus with respect to a test stimulus targeted to the cortical hotspot of the abductor pollicis brevis (APB) in order to study their effects on motor evoked potentials. We further applied a two-coil protocol with the conditioning stimulus given by an oval coil only to the surroundings of the APB hotspot, to which a subsequent test stimulus was administered with a figure-of-eight coil. The strongest SICI occurred at ISIs below 1 ms and at ISIs around 2.5 ms. These ISIs increased when the conditioning stimulus receded from the APB hotspot. Our two-coil paired-pulse TMS study suggests that SICI at ISIs of 0.5 and 2.5 ms originate from different mechanisms or neuronal elements.",
keywords = "Motor cortex, Motor evoked potential, Multi-locus transcranial magnetic stimulation, Short-interval intracortical inhibition, Transcranial magnetic stimulation, Transducer",
author = "Nieminen, {Jaakko O.} and Koponen, {Lari M.} and Niko M{\"a}kel{\"a} and Souza, {Victor Hugo} and Matti Stenroos and Ilmoniemi, {Risto J.}",
year = "2019",
month = "12",
day = "1",
doi = "10.1016/j.neuroimage.2019.116194",
language = "English",
volume = "203",
journal = "NeuroImage",
issn = "1053-8119",

}

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TY - JOUR

T1 - Short-interval intracortical inhibition in human primary motor cortex

T2 - A multi-locus transcranial magnetic stimulation study

AU - Nieminen, Jaakko O.

AU - Koponen, Lari M.

AU - Mäkelä, Niko

AU - Souza, Victor Hugo

AU - Stenroos, Matti

AU - Ilmoniemi, Risto J.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Short-interval intracortical inhibition (SICI) has been studied with paired-pulse transcranial magnetic stimulation (TMS) by administering two pulses at a millisecond-scale interstimulus interval (ISI) to a single cortical target. It has, however, been difficult to study the interaction of nearby cortical targets with paired-pulse TMS. To overcome this limitation, we have developed a multi-locus TMS (mTMS) device, which allows controlling the stimulus location electronically. Here, we applied mTMS to study SICI in primary motor cortex with paired pulses targeted to adjacent locations, aiming to quantify the extent of the cortical region producing SICI in the location of a test stimulus. We varied the location and timing of the conditioning stimulus with respect to a test stimulus targeted to the cortical hotspot of the abductor pollicis brevis (APB) in order to study their effects on motor evoked potentials. We further applied a two-coil protocol with the conditioning stimulus given by an oval coil only to the surroundings of the APB hotspot, to which a subsequent test stimulus was administered with a figure-of-eight coil. The strongest SICI occurred at ISIs below 1 ms and at ISIs around 2.5 ms. These ISIs increased when the conditioning stimulus receded from the APB hotspot. Our two-coil paired-pulse TMS study suggests that SICI at ISIs of 0.5 and 2.5 ms originate from different mechanisms or neuronal elements.

AB - Short-interval intracortical inhibition (SICI) has been studied with paired-pulse transcranial magnetic stimulation (TMS) by administering two pulses at a millisecond-scale interstimulus interval (ISI) to a single cortical target. It has, however, been difficult to study the interaction of nearby cortical targets with paired-pulse TMS. To overcome this limitation, we have developed a multi-locus TMS (mTMS) device, which allows controlling the stimulus location electronically. Here, we applied mTMS to study SICI in primary motor cortex with paired pulses targeted to adjacent locations, aiming to quantify the extent of the cortical region producing SICI in the location of a test stimulus. We varied the location and timing of the conditioning stimulus with respect to a test stimulus targeted to the cortical hotspot of the abductor pollicis brevis (APB) in order to study their effects on motor evoked potentials. We further applied a two-coil protocol with the conditioning stimulus given by an oval coil only to the surroundings of the APB hotspot, to which a subsequent test stimulus was administered with a figure-of-eight coil. The strongest SICI occurred at ISIs below 1 ms and at ISIs around 2.5 ms. These ISIs increased when the conditioning stimulus receded from the APB hotspot. Our two-coil paired-pulse TMS study suggests that SICI at ISIs of 0.5 and 2.5 ms originate from different mechanisms or neuronal elements.

KW - Motor cortex

KW - Motor evoked potential

KW - Multi-locus transcranial magnetic stimulation

KW - Short-interval intracortical inhibition

KW - Transcranial magnetic stimulation

KW - Transducer

UR - http://www.scopus.com/inward/record.url?scp=85072514604&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2019.116194

DO - 10.1016/j.neuroimage.2019.116194

M3 - Article

VL - 203

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 116194

ER -

ID: 37213762