Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes

M. Karoliina Hirvonen, Niina Lietzén, Robert Moulder, Santosh D. Bhosale, Jaakko Koskenniemi, Mari Vähä-Mäkilä, Mirja Nurmio, Matej Orešič, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Heikki Hyöty, Harri Lähdesmäki, Mikael Knip, Lu Cheng*, Riitta Lahesmaa*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging process. To address this concern, we used mass spectrometry-based proteomics to analyse longitudinal pre-onset plasma sample series from children positive for multiple islet autoantibodies who had rapidly progressed to type 1 diabetes before 4 years of age (n = 10) and compared these with similar measurements from matched children who were either positive for a single autoantibody (n = 10) or autoantibody negative (n = 10). Following statistical analysis of the longitudinal data, targeted serum proteomics was used to verify 11 proteins putatively associated with the disease development in a similar yet independent and larger cohort of children who progressed to the disease within 5 years of age (n = 31) and matched autoantibody negative children (n = 31). These data reiterated extensive age-related trends for protein levels in young children. Further, these analyses demonstrated that the serum levels of two peptides unique for apolipoprotein C1 (APOC1) were decreased after the appearance of the first islet autoantibody and remained relatively less abundant in children who progressed to type 1 diabetes, in comparison to autoantibody negative children.

Original languageEnglish
Article number15941
Pages (from-to)1-11
Number of pages11
JournalScientific Reports
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 2023
MoE publication typeA1 Journal article-refereed

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