Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

King Hang Aaron Lau; Valeria Castelletto; Thomas Kendall; Jan Sefcik; Ian W. Hamley; Mehedi Reza; Janne Ruokolainen

doi:10.1039/c6cc09888f

Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

King Hang Aaron Lau^*, Valeria Castelletto, Thomas Kendall, Jan Sefcik, Ian W. Hamley, Mehedi Reza, Janne Ruokolainen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomimetic nanospheres.

Original language	English
Pages (from-to)	2178-2181
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	13
DOIs	https://doi.org/10.1039/c6cc09888f
Publication status	Published - 2017
MoE publication type	A1 Journal article-refereed

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10.1039/c6cc09888f

c6cc09888fFinal published version, 2.11 MBLicence: CC BY

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abstract = "Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomimetic nanospheres.",

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AU - Hamley, Ian W.

AU - Reza, Mehedi

AU - Ruokolainen, Janne

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AB - Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small peptidomimetic nanospheres.

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JO - Chemical Communications

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Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

Abstract

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