Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Steven Kirkham; Valeria Castelletto; Ian William Hamley; Katsuaki Inoue; Robert Rambo; Mehedi Reza; Janne Ruokolainen

doi:10.1002/cphc.201600308

Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Steven Kirkham, Valeria Castelletto, Ian William Hamley^*, Katsuaki Inoue, Robert Rambo, Mehedi Reza, Janne Ruokolainen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

37 Citations (Scopus)

Abstract

The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl₂, in contrast to claims in the literature that CaCl₂ is required for micellization.

Original language	English
Pages (from-to)	2118 – 2122
Journal	ChemPhysChem
Volume	17
Issue number	14
DOIs	https://doi.org/10.1002/cphc.201600308
Publication status	Published - 18 Jul 2016
MoE publication type	A1 Journal article-refereed

Keywords

Antimicrobial peptides
Lipopeptide
Micelles
Secondary structure
Self-assembly

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10.1002/cphc.201600308

http://centaur.reading.ac.uk/66618/

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abstract = "The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.",

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AU - Inoue, Katsuaki

AU - Rambo, Robert

AU - Reza, Mehedi

AU - Ruokolainen, Janne

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KW - Antimicrobial peptides

KW - Lipopeptide

KW - Micelles

KW - Secondary structure

KW - Self-assembly

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Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Abstract

Keywords

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Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Abstract

Keywords

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