Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Steven Kirkham, Valeria Castelletto, Ian William Hamley*, Katsuaki Inoue, Robert Rambo, Mehedi Reza, Janne Ruokolainen

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Abstract

The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.

Original languageEnglish
Pages (from-to)2118 – 2122
JournalChemPhysChem
Volume17
Issue number14
DOIs
Publication statusPublished - 18 Jul 2016
MoE publication typeA1 Journal article-refereed

Keywords

  • Antimicrobial peptides
  • Lipopeptide
  • Micelles
  • Secondary structure
  • Self-assembly

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