Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Steven Kirkham; Valeria Castelletto; Ian William Hamley; Katsuaki Inoue; Robert Rambo; Mehedi Reza; Janne Ruokolainen

doi:10.1002/cphc.201600308

Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Steven Kirkham, Valeria Castelletto, Ian William Hamley^*, Katsuaki Inoue, Robert Rambo, Mehedi Reza, Janne Ruokolainen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

21 Citations (Scopus)

Abstract

The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl₂, in contrast to claims in the literature that CaCl₂ is required for micellization.

Original language	English
Pages (from-to)	2118 – 2122
Journal	ChemPhysChem
Volume	17
Issue number	14
DOIs	https://doi.org/10.1002/cphc.201600308
Publication status	Published - 18 Jul 2016
MoE publication type	A1 Journal article-refereed

Keywords

Antimicrobial peptides
Lipopeptide
Micelles
Secondary structure
Self-assembly

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http://centaur.reading.ac.uk/66618/

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title = "Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride",

abstract = "The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.",

keywords = "Antimicrobial peptides, Lipopeptide, Micelles, Secondary structure, Self-assembly",

author = "Steven Kirkham and Valeria Castelletto and Hamley, {Ian William} and Katsuaki Inoue and Robert Rambo and Mehedi Reza and Janne Ruokolainen",

year = "2016",

month = jul,

day = "18",

doi = "10.1002/cphc.201600308",

language = "English",

volume = "17",

pages = "2118 – 2122",

journal = "ChemPhysChem",

issn = "1439-4235",

number = "14",

}

Self-Assembly of the Cyclic Lipopeptide Daptomycin : Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride. / Kirkham, Steven; Castelletto, Valeria; Hamley, Ian William; Inoue, Katsuaki; Rambo, Robert; Reza, Mehedi; Ruokolainen, Janne.

In: ChemPhysChem, Vol. 17, No. 14, 18.07.2016, p. 2118 – 2122.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Self-Assembly of the Cyclic Lipopeptide Daptomycin

T2 - Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

AU - Kirkham, Steven

AU - Castelletto, Valeria

AU - Hamley, Ian William

AU - Inoue, Katsuaki

AU - Rambo, Robert

AU - Reza, Mehedi

AU - Ruokolainen, Janne

PY - 2016/7/18

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KW - Antimicrobial peptides

KW - Lipopeptide

KW - Micelles

KW - Secondary structure

KW - Self-assembly

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DO - 10.1002/cphc.201600308

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Self-Assembly of the Cyclic Lipopeptide Daptomycin: Spherical Micelle Formation Does Not Depend on the Presence of Calcium Chloride

Abstract

Keywords

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