Self-assembled stimuli-responsive polyrotaxane core-shell particles

Blaise L. Tardy, Henk H. Dam, Marloes M J Kamphuis, Joseph J. Richardson, Frank Caruso*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

33 Citations (Scopus)

Abstract

Thermodynamically assembled core-shell nanocarriers are potential candidates for drug delivery applications due to their submicrometer size and the ability to load drugs into their hydrophobic core. Herein, we describe the formation of core-shell particles that consist of noncovalent polymers, that is, polyrotaxanes (PRXs), that form an α-cyclodextrin (αCD) core surrounded by a corona of low-fouling poly(ethylene glycol) (PEG). The PRX core-shell particles are able to sequester small organic molecules, such as pyrene and calcein, releasing these small molecules during degradation. The small, cellular peptide, glutathione, was used to degrade the particles through the reductive cleavage of disulfide bonds that stabilize the individual PRX polymers. Cleavage of a single bond allows for the degradation of the supramolecular-polymer, making these PRX core-shell particles highly responsive. Furthermore, these particles demonstrate negligible cytotoxicity in mammalian cells, making them promising carriers for future drug delivery research.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalBiomacromolecules
Volume15
Issue number1
DOIs
Publication statusPublished - 13 Jan 2014
MoE publication typeA1 Journal article-refereed

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