Selective detection of morphine in the presence of paracetamol with anodically pretreated dual layer Ti/tetrahedral amorphous carbon electrodes

Niklas Wester*, Jarkko Etula, Tuomas Lilius, Sami Sainio, Tomi Laurila, Jari Koskinen

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

15 Citations (Scopus)

Abstract

We investigated the effect of anodic treatment of titanium/tetrahedral amorphous carbon electrodes on the electrochemical detection of morphine and paracetamol. The anodic treatment caused both oxidation of the carbon and, more importantly, exposure and oxidation of the underlying Ti layer. This treatment anodically shifted the oxidation potential of paracetamol while that of morphine remained unaffected. The resulting electrode also showed better selectivity than a ta-C electrode without Ti. After anodic treatment at 2.5 V, selective detection of morphine with a physiologically meaningful detection limit of 9.8 nM and a linear range of 0.1–10 μM was obtained in the presence of 100 μM paracetamol.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalElectrochemistry Communications
Volume86
DOIs
Publication statusPublished - 1 Jan 2018
MoE publication typeA1 Journal article-refereed

Keywords

  • Morphine
  • Paracetamol
  • Tetrahedral amorphous carbon
  • Titanium
  • Voltammetry

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