Search for antibody catalysts for the ene reaction

T Hase*, G Brunow, A Hase, M Kodaka, C Neagu, T Nevanen, T Teeri, O Teleman, E Tiainen, J YliKauhaluoma, A Yliniemela

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The design, computational studies and synthesis of transition state analogs for an ene reaction are described. The most promising analogs were used to elicit antibodies that should catalyze an ene reaction between maleimide and 1-decene. Preliminary results indicate that successful catalytic antibodies for the ene reaction can be produced in this manner. In parallel, an antibody library is being developed for the same purpose.

Original languageEnglish
Pages (from-to)605-608
Number of pages4
JournalPure and Applied Chemistry
Volume68
Issue number3
Publication statusPublished - Mar 1996
MoE publication typeA1 Journal article-refereed
EventInternational Conference on Organic Synthesis - Bangalore, India
Duration: 11 Dec 199416 Dec 1994
Conference number: 10

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