Scavenging properties of plant-derived natural biomolecule para-coumaric acid in the prevention of oxidative stress-induced diseases

Shubhadeep Roychoudhury*, Barnali Sinha, Birupakshya Paul Choudhury, Niraj Kumar Jha, Partha Palit, Surekha Kundu, Subhash C. Mandal, Adriana Kolesarova, Mokhtar Ibrahim Yousef, Janne Ruokolainen, Petr Slama, Kavindra Kumar Kesari

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

4 Citations (Scopus)
17 Downloads (Pure)

Abstract

Para-coumaric acid (p-CA) is a plant derived secondary metabolite belonging to the phenolic compounds. It is widely distributed in the plant kingdom and found mainly in fruits, vegetables, and cereals. Various in vivo and in vitro studies have revealed its scavenging and antioxidative properties in the reduction of oxidative stress and inflammatory reactions. This evidence-based review focuses on the protective role of p-CA including its therapeutic potential. p-CA and its conjugates possesses various bioactivities such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, and anti-melanogenic properties. Due to its potent free radical scavenging activity, it can mitigate the ill effects of various diseases including arthritis, neurological disorders, and cardio-vascular diseases. Recent studies have revealed that p-CA can ameliorate the harmful effects associated with oxidative stress in the reproductive system, also by inhibiting enzymes linked with erectile function.

Original languageEnglish
Article number1205
Number of pages18
JournalAntioxidants
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2021
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Anti-cancer
  • Anti-diabetic
  • Anti-inflammatory
  • Anti-melanogenic
  • Antioxidant
  • Disease
  • Oxidative stress
  • Para-coumaric acid
  • ROS

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