Reproducibility of corticokinematic coherence

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Reproducibility of corticokinematic coherence. / Piitulainen, Harri; Illman, Mia; Laaksonen, Kristina; Jousmäki, Veikko; Forss, Nina.

In: NeuroImage, Vol. 179, 01.10.2018, p. 596-603.

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@article{387d9ca0f67e4b9b89c35c03ec5b3b4f,
title = "Reproducibility of corticokinematic coherence",
abstract = "Corticokinematic coherence (CKC) between limb kinematics and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. However, it is unclear whether strength of CKC is reproducible across measurement sessions. We thus examined reproducibility of CKC in a follow-up study. Thirteen healthy right-handed volunteers (7 females, 21.7 ± 4.3 yrs) were measured using MEG in two separate sessions 12.6 ± 1.3 months apart. The participant was seated and relaxed while his/her dominant or non-dominant index finger was continuously moved at 3 Hz (4 min for each hand) using a pneumatic movement actuator. Finger kinematics were recorded with a 3-axis accelerometer. Coherence was computed between finger acceleration and MEG signals. CKC strength was defined as the peak coherence value at 3 Hz form a single sensor among 40 pre-selected Rolandic gradiometers contralateral to the movement. Pneumatic movement actuator provided stable proprioceptive stimuli and significant CKC responses peaking at the contralateral Rolandic sensors. In the group level, CKC strength did not differ between the sessions in dominant (Day-1 0.40 ± 0.19 vs. Day-2 0.41 ± 0.17) or non-dominant (0.35 ± 0.16 vs. 0.36 ± 0.17) hand, nor between the hands. Intraclass-correlation coefficient (ICC) values indicated excellent inter-session reproducibility for CKC strength for both dominant (0.86) and non-dominant (0.97) hand. However, some participants showed pronounced inter-session variability in CKC strength, but only for the dominant hand. CKC is a promising tool to study proprioception in long-term longitudinal studies in the group level to follow, e.g., integrity of cortical proprioceptive processing with motor functions after stroke.",
keywords = "Kinematics, Magnetoencephalography, Movement evoked field, Proprioception, Repeatability, Somatosensory",
author = "Harri Piitulainen and Mia Illman and Kristina Laaksonen and Veikko Jousm{\"a}ki and Nina Forss",
year = "2018",
month = "10",
day = "1",
doi = "10.1016/j.neuroimage.2018.06.078",
language = "English",
volume = "179",
pages = "596--603",
journal = "NeuroImage",
issn = "1053-8119",

}

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TY - JOUR

T1 - Reproducibility of corticokinematic coherence

AU - Piitulainen, Harri

AU - Illman, Mia

AU - Laaksonen, Kristina

AU - Jousmäki, Veikko

AU - Forss, Nina

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Corticokinematic coherence (CKC) between limb kinematics and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. However, it is unclear whether strength of CKC is reproducible across measurement sessions. We thus examined reproducibility of CKC in a follow-up study. Thirteen healthy right-handed volunteers (7 females, 21.7 ± 4.3 yrs) were measured using MEG in two separate sessions 12.6 ± 1.3 months apart. The participant was seated and relaxed while his/her dominant or non-dominant index finger was continuously moved at 3 Hz (4 min for each hand) using a pneumatic movement actuator. Finger kinematics were recorded with a 3-axis accelerometer. Coherence was computed between finger acceleration and MEG signals. CKC strength was defined as the peak coherence value at 3 Hz form a single sensor among 40 pre-selected Rolandic gradiometers contralateral to the movement. Pneumatic movement actuator provided stable proprioceptive stimuli and significant CKC responses peaking at the contralateral Rolandic sensors. In the group level, CKC strength did not differ between the sessions in dominant (Day-1 0.40 ± 0.19 vs. Day-2 0.41 ± 0.17) or non-dominant (0.35 ± 0.16 vs. 0.36 ± 0.17) hand, nor between the hands. Intraclass-correlation coefficient (ICC) values indicated excellent inter-session reproducibility for CKC strength for both dominant (0.86) and non-dominant (0.97) hand. However, some participants showed pronounced inter-session variability in CKC strength, but only for the dominant hand. CKC is a promising tool to study proprioception in long-term longitudinal studies in the group level to follow, e.g., integrity of cortical proprioceptive processing with motor functions after stroke.

AB - Corticokinematic coherence (CKC) between limb kinematics and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. However, it is unclear whether strength of CKC is reproducible across measurement sessions. We thus examined reproducibility of CKC in a follow-up study. Thirteen healthy right-handed volunteers (7 females, 21.7 ± 4.3 yrs) were measured using MEG in two separate sessions 12.6 ± 1.3 months apart. The participant was seated and relaxed while his/her dominant or non-dominant index finger was continuously moved at 3 Hz (4 min for each hand) using a pneumatic movement actuator. Finger kinematics were recorded with a 3-axis accelerometer. Coherence was computed between finger acceleration and MEG signals. CKC strength was defined as the peak coherence value at 3 Hz form a single sensor among 40 pre-selected Rolandic gradiometers contralateral to the movement. Pneumatic movement actuator provided stable proprioceptive stimuli and significant CKC responses peaking at the contralateral Rolandic sensors. In the group level, CKC strength did not differ between the sessions in dominant (Day-1 0.40 ± 0.19 vs. Day-2 0.41 ± 0.17) or non-dominant (0.35 ± 0.16 vs. 0.36 ± 0.17) hand, nor between the hands. Intraclass-correlation coefficient (ICC) values indicated excellent inter-session reproducibility for CKC strength for both dominant (0.86) and non-dominant (0.97) hand. However, some participants showed pronounced inter-session variability in CKC strength, but only for the dominant hand. CKC is a promising tool to study proprioception in long-term longitudinal studies in the group level to follow, e.g., integrity of cortical proprioceptive processing with motor functions after stroke.

KW - Kinematics

KW - Magnetoencephalography

KW - Movement evoked field

KW - Proprioception

KW - Repeatability

KW - Somatosensory

UR - http://www.scopus.com/inward/record.url?scp=85049422156&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2018.06.078

DO - 10.1016/j.neuroimage.2018.06.078

M3 - Article

VL - 179

SP - 596

EP - 603

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -

ID: 26595914