Reliable self-assembly by self-triggered activation of enveloped DNA tiles

Vinay Kumar Gautam, Pauline C. Haddow, Martin Kuiper

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

7 Citations (Scopus)


Although the design of DNA tiles has been optimised for efficient and specific self-assembly, assembly errors occur so often that applications for molecular computation remain limited. We propose the use of an enveloped tile consisting of a DX- base tile that carries a protector tile to suppress erroneous tile assembly. The design of the enveloped tile promotes the dissociation of the protector tile from the base tile through a self-triggered activation process, which keeps the outputs of the base tile stay protected until both base tile inputs have bonded correctly to the assembly. The enveloped tile design, the self-triggered activation that removes the protector tile and preliminary modelling results are presented.

Original languageEnglish
Title of host publicationTheory and Practice of Natural Computing - Second International Conference, TPNC 2013, Proceedings
Number of pages12
Publication statusPublished - 1 Dec 2013
MoE publication typeA4 Article in a conference publication
EventInternational Conference on the Theory and Practice of Natural Computing - Caceres, Spain
Duration: 3 Dec 20135 Dec 2013
Conference number: 2

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8273 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


ConferenceInternational Conference on the Theory and Practice of Natural Computing
Abbreviated titleTPNC


  • DNA tile
  • Enveloped Tile
  • Molecular computation
  • Protector Tile
  • Self-assembly


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