Reliable recording and analysis of MEG-based corticokinematic coherence in the presence of strong magnetic artifacts

Research output: Contribution to journalArticleScientificpeer-review

Researchers

Research units

  • Karolinska Institutet

Abstract

Objective: Corticokinematic coherence (CKC) is the coupling between magnetoencephalographic (MEG) signals and limb kinematics during fast movements. Our objective was to assess the robustness of CKC-based identification of the primary sensorimotor (SM1) cortex of subjects producing strong magnetic artifacts when the MEG signals were cleaned with temporal signal space separation (tSSS).

Methods: We recorded MEG during active and passive forefinger movements and during median-nerve stimulation in the following conditions: (1) artifact-free, (2) a magnetic wire attached to the scalp at C3 location, and (3) a magnetic wire attached behind the lower central incisors. Data were preprocessed with tSSS and analyzed using standard CKC methods, somatosensory evoked fields (SEFs), and dipole modeling.

Result: Artifacts were effectively suppressed by tSSS, enabling successful identification of the SM1 cortex in all subjects based on CKC and SEFs. The sources were in artifact conditions similar to 5 mm away from the sources identified in artifact-free conditions.

Conclusion: tSSS suppressed artifacts strongly enough to enable reliable identification of the SM1 cortex on the basis of CKC mapping, with localization accuracy comparable to SEF-based mapping.

Significance: The results suggest that CKC can be used for SM1 cortex identification and for studies of proprioception even in patients implanted with magnetic material. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Details

Original languageEnglish
Pages (from-to)1460-1469
Number of pages10
JournalClinical Neurophysiology
Volume127
Issue number2
Publication statusPublished - Feb 2016
MoE publication typeA1 Journal article-refereed

    Research areas

  • Magnetoencephalography, Artifacts, Signal-space separation, Corticokinematic coherence, Human brain, Proprioception, Functional mapping, SIGNAL-SPACE SEPARATION, FUNCTIONAL MRI, BRAIN-TUMORS, CLINICAL-APPLICATIONS, PASSIVE FINGER, CENTRAL SULCUS, MOTOR-CORTEX, MAGNETOENCEPHALOGRAPHY, LOCALIZATION, STIMULATION

ID: 1571632