Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex

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Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex. / Lin, Fa Hsuan; Polimeni, Jonathan R.; Lin, Jo-Fu Lotus; Tsai, Kevin W.K.; Chu, Ying-Hua; Wu, Pu Yeh; Li, Yi Tien; Hsu, Yi Cheng; Tsai, Shang-Yueh; Kuo, Wen-Jui.

In: NeuroImage, Vol. 164, 2018, p. 194-201.

Research output: Contribution to journalArticleScientificpeer-review

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Lin, FH, Polimeni, JR, Lin, J-FL, Tsai, KWK, Chu, Y-H, Wu, PY, Li, YT, Hsu, YC, Tsai, S-Y & Kuo, W-J 2018, 'Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex', NeuroImage, vol. 164, pp. 194-201. https://doi.org/10.1016/j.neuroimage.2017.01.041

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Lin, Fa Hsuan ; Polimeni, Jonathan R. ; Lin, Jo-Fu Lotus ; Tsai, Kevin W.K. ; Chu, Ying-Hua ; Wu, Pu Yeh ; Li, Yi Tien ; Hsu, Yi Cheng ; Tsai, Shang-Yueh ; Kuo, Wen-Jui. / Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex. In: NeuroImage. 2018 ; Vol. 164. pp. 194-201.

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@article{32f0c87d31284555882c8e7124171d5f,
title = "Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex",
abstract = "The blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signal is a robust surrogate for local neuronal activity. However, it has been shown to vary substantially across subjects, brain regions, and repetitive measurements. This variability represents a limit to the precision of the BOLD response and the ability to reliably discriminate brain hemodynamic responses elicited by external stimuli or behavior that are nearby in time. While the temporal variability of the BOLD signal at human visual cortex has been found in the range of a few hundreds of milliseconds, the spatial distributions of the average and standard deviation of this temporal variability have not been quantitatively characterized. Here we use fMRI measurements with a high sampling rate (10. Hz) to map the latency, intra- and inter-subject variability of the evoked BOLD signal in human primary (V1) visual cortices using an event-related fMRI paradigm. The latency relative to the average BOLD signal evoked by 30 stimuli was estimated to be 0.03±0.20. s. Within V1, the absolute value of the relative BOLD latency was found correlated to intra- and inter-subject temporal variability. After comparing these measures to retinotopic maps, we found that locations with V1 areas sensitive to smaller eccentricity have later responses and smaller inter-subject variabilities. These correlations were found from data with either short inter-stimulus interval (ISI; average 4. s) or long ISI (average 30. s). Maps of the relative latency as well as inter-/intra-subject variability were found visually asymmetric between hemispheres. Our results suggest that the latency and variability of regional BOLD signal measured with high spatiotemporal resolution may be used to detect regional differences in hemodynamics to inform fMRI studies. However, the physiological origins of timing index distributions and their hemispheric asymmetry remain to be investigated.",
keywords = "FMRI, Hemodynamics, Precision, Retinotopy, Stability, V1",
author = "Lin, {Fa Hsuan} and Polimeni, {Jonathan R.} and Lin, {Jo-Fu Lotus} and Tsai, {Kevin W.K.} and Ying-Hua Chu and Wu, {Pu Yeh} and Li, {Yi Tien} and Hsu, {Yi Cheng} and Shang-Yueh Tsai and Wen-Jui Kuo",
year = "2018",
doi = "10.1016/j.neuroimage.2017.01.041",
language = "English",
volume = "164",
pages = "194--201",
journal = "NeuroImage",
issn = "1053-8119",

}

RIS - Download

TY - JOUR

T1 - Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex

AU - Lin, Fa Hsuan

AU - Polimeni, Jonathan R.

AU - Lin, Jo-Fu Lotus

AU - Tsai, Kevin W.K.

AU - Chu, Ying-Hua

AU - Wu, Pu Yeh

AU - Li, Yi Tien

AU - Hsu, Yi Cheng

AU - Tsai, Shang-Yueh

AU - Kuo, Wen-Jui

PY - 2018

Y1 - 2018

N2 - The blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signal is a robust surrogate for local neuronal activity. However, it has been shown to vary substantially across subjects, brain regions, and repetitive measurements. This variability represents a limit to the precision of the BOLD response and the ability to reliably discriminate brain hemodynamic responses elicited by external stimuli or behavior that are nearby in time. While the temporal variability of the BOLD signal at human visual cortex has been found in the range of a few hundreds of milliseconds, the spatial distributions of the average and standard deviation of this temporal variability have not been quantitatively characterized. Here we use fMRI measurements with a high sampling rate (10. Hz) to map the latency, intra- and inter-subject variability of the evoked BOLD signal in human primary (V1) visual cortices using an event-related fMRI paradigm. The latency relative to the average BOLD signal evoked by 30 stimuli was estimated to be 0.03±0.20. s. Within V1, the absolute value of the relative BOLD latency was found correlated to intra- and inter-subject temporal variability. After comparing these measures to retinotopic maps, we found that locations with V1 areas sensitive to smaller eccentricity have later responses and smaller inter-subject variabilities. These correlations were found from data with either short inter-stimulus interval (ISI; average 4. s) or long ISI (average 30. s). Maps of the relative latency as well as inter-/intra-subject variability were found visually asymmetric between hemispheres. Our results suggest that the latency and variability of regional BOLD signal measured with high spatiotemporal resolution may be used to detect regional differences in hemodynamics to inform fMRI studies. However, the physiological origins of timing index distributions and their hemispheric asymmetry remain to be investigated.

AB - The blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signal is a robust surrogate for local neuronal activity. However, it has been shown to vary substantially across subjects, brain regions, and repetitive measurements. This variability represents a limit to the precision of the BOLD response and the ability to reliably discriminate brain hemodynamic responses elicited by external stimuli or behavior that are nearby in time. While the temporal variability of the BOLD signal at human visual cortex has been found in the range of a few hundreds of milliseconds, the spatial distributions of the average and standard deviation of this temporal variability have not been quantitatively characterized. Here we use fMRI measurements with a high sampling rate (10. Hz) to map the latency, intra- and inter-subject variability of the evoked BOLD signal in human primary (V1) visual cortices using an event-related fMRI paradigm. The latency relative to the average BOLD signal evoked by 30 stimuli was estimated to be 0.03±0.20. s. Within V1, the absolute value of the relative BOLD latency was found correlated to intra- and inter-subject temporal variability. After comparing these measures to retinotopic maps, we found that locations with V1 areas sensitive to smaller eccentricity have later responses and smaller inter-subject variabilities. These correlations were found from data with either short inter-stimulus interval (ISI; average 4. s) or long ISI (average 30. s). Maps of the relative latency as well as inter-/intra-subject variability were found visually asymmetric between hemispheres. Our results suggest that the latency and variability of regional BOLD signal measured with high spatiotemporal resolution may be used to detect regional differences in hemodynamics to inform fMRI studies. However, the physiological origins of timing index distributions and their hemispheric asymmetry remain to be investigated.

KW - FMRI

KW - Hemodynamics

KW - Precision

KW - Retinotopy

KW - Stability

KW - V1

UR - http://www.scopus.com/inward/record.url?scp=85021224414&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2017.01.041

DO - 10.1016/j.neuroimage.2017.01.041

M3 - Article

VL - 164

SP - 194

EP - 201

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -

ID: 14299338