Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration

Haniyeh Najafi, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali*, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

4 Citations (Scopus)


The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility, tunable mechanical stability, injectability, trigger capability, lack of immunogenic reactions, and the ability to load cells and active pharmaceutical agents for tissue regeneration. Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals, which can mimic the extracellular matrix. Thus, peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods. This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic self-complementary peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like) peptides. Special attention is given to the main bioactive peptides, the role and importance of self-assembled peptide hydrogels, and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.

Original languageEnglish
Pages (from-to)735-756
Number of pages22
JournalBio-Design and Manufacturing
Issue number4
Early online date20 Jul 2021
Publication statusPublished - Dec 2021
MoE publication typeA2 Review article in a scientific journal


  • Bone-repair material
  • Dental regeneration
  • Hard tissue engineering
  • Hydrogel
  • Self-assembled peptides


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